Treatment of alpha (0)-thalassemia (--SEA/--SEA)via serial fetal and post-natal transfusions:Can early fetal intervention improve outcomes?. Chmait RH,Baskin JL,Carson S,et al. Hematology . 2014Chmait RH, Baskin JL, Carson S, Randolph LM, Hamilton A (2015) Treatment of alpha...
Alpha (α)-thalassemia represents a group of recessively inherited hemoglobin disorders marked by deficient or absent synthesis of 1 to all 4 of the α-globin genes. Inactivation of 3 α-globin genes – either by deletional or nondeletional mutations – results in hemoglobin H (Hb H) disease...
Letter to the Editor: Lumping Juberg-Marsidi syndrome and X-linked α-thalassemia/mental retardation syndrome? alpha-ThalassemiaAbnormalities, MultipleInfantMental RetardationGenetic LinkageMaleSaugier-Veber P, Munnich A, Lyonnet S, Toutain A, Moraine C, Piussan C, ... P Saugier-Veber,A Munnich...
Treatment depends of the type of thalassemia. The thalassemia traits require no treatment or long-term monitoring. The intermediate types may require occasional RBC transfusions if symptomatic from anemia or if growth is impaired, whereas beta thalassemia major patients will require repeated RBC transfus...
Loss of α-hemoglobin–stabilizing protein impairs erythropoiesis and exacerbates β-thalassemia. J. Clin. Investig. 114, 1457–1466 (2004). Article CAS PubMed PubMed Central Google Scholar Yu, X. et al. An erythroid chaperone that facilitates folding of α-globin subunits for hemoglobin ...
The counteracting effect of antioxidants on lipid peroxidation and their protective effect against oxidative damage of erythrocytes in β-thalassemia were demonstrated[37]. It has been suggested that L-carnitine may act via stabilization of the red blood cell membrane, thereby increasing the erythrocyte...
ALPHA-ThalassemiaDIAGNOSISTHERAPEUTICSNo abstract is available for this article.doi:10.1002/uog.14368M. Debska2nd Department of Obstetrics and Gynecology The Medical Center of Postgraduate Education, The Center of Medical Postgraduate Education Warsaw Poland...
Powder mixture for controlling deficits in alpha thalassemia patients with haemoglobin production, comprising:a pharmaceutically acceptable carrier;an amplification primer pair;a nucleic acid molecule;a beta globine;a gamma globine and/or a carbonic anhydrase;a chemical compound of the structure: R1-C(...
Guidelines for non–transfusion-dependent thalassemia (NTDT) recommend raising hemoglobin (Hb) by ≥1 g/dL to reduce morbidities from IE and anemia. No oral disease-modifying therapies are approved for the treatment of β-thalassemia, and no agents are approved for α-thalassemia. Mitapivat is...
The response to the treatment was monitored using the hemoglobin levels, the red cell count, the reticulocyte count and the transfusional requirement. This report points out the usefulness of the treatment with interferon alpha in two Sicilian beta thalassemia carriers, in which the therapy was ...