Styles, LVichinsky, EFoote, DQuirolo, KGenetics in MedicineVichinsky, E. P. (2009). Alpha thalassemia major-new mutations, intrauterine man- agement, and outcomes. Hematology Am. Soc. Hematol. Educ. Program 35-41. doi: 10.1182/asheducation-2009.1.35...
Historically, fetal α-thalassemia major was considered to be a uniformly lethal condition, but with the advent of intrauterine transfusions, increasing numbers of live births have been reported; however, in the absence of curative therapy, prenatal treatment raises ethical dilemmas and requires ...
RBC precursors are so severely affected that they may die in the bone marrow, resulting in ineffective erythropoiesis (more commonly seen in beta thalassemia intermedia and major). In other situations
Twitter Google Share on Facebook alpha (redirected fromAlpha toxin) Thesaurus Medical Financial Encyclopedia Wikipedia al·pha (ăl′fə) n. 1.The first letter of the Greek alphabet. See Table atalphabet. 2.The first of a series; the beginning. ...
alpha-ThalassemiaAbnormalities, MultipleInfantMental RetardationGenetic LinkageMaleSaugier-Veber P, Munnich A, Lyonnet S, Toutain A, Moraine C, Piussan C, ... P Saugier-Veber,A Munnich,S Lyonnet,... - 《American Journal of Medical Genetics》 被引量: 206发表: 1995年 Recombinant Leishmania ma...
A Novel alpha-Thalassemia Nonsense Mutation on the alpha2-Globin Gene: HBA2: c.184A>T 来自 掌桥科研 喜欢 0 阅读量: 10 作者: Yuan LiangQi PengMiao LiSiping LiWenrui Li Xiaomei Lu 摘要: We report a novel mutation on the alpha2-globin gene, HBA2: c.184A>T, detected in a ...
When the disorder develops later during life, adiagnosis of beta thalassemia intermedia is given; individuals may only require blood transfusions on rare, specific instances. Beta thalassemia major, also known as Cooley's anemia, is the most severe form of beta thalassemia. ...
To test the first of these hypotheses in a controlled setting, we have initiated a phase 1 clinical trial of IUHCT in fetuses with alpha thalassemia major (ATM), who already require a fetal intervention (in utero transfusions (IUT)) to survive the pregnancy. We present interim results from...
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Unrelated Donor Umbilical Cord Blood Transplant Following Intrauterine Transfusions for Treatment of Alpha Thalassemia Major. Based on the family's nationality and history of previous fetal loss, the suspicion of a0thalassemia was raised. Umbilical cord blood sampling revealed a hypochromic, microcytic ane...