The thalassemias are a group of inherited hematologic disorders caused by defects in the synthesis of one or more of the hemoglobin chains. Alpha tha..
Two gene deletions cause alpha thalassemia trait (also known as alpha thalassemia minor), typically a diagnosis of exclusion in patients who present with microcytosis (with or without mild anemia), normal iron stores, and normal HbA2. The deletions can occur on the same (cis) or different (...
and beta thalassemias are likewise the result of decreased (β+) or absent (β0) production of beta globin chains (Muncie and Campbell 2009;Cunningham 2010). The thalassemias are found most commonly
Define Alpha toxin. Alpha toxin synonyms, Alpha toxin pronunciation, Alpha toxin translation, English dictionary definition of Alpha toxin. n. 1. The first letter of the Greek alphabet. See Table at alphabet. 2. The first of a series; the beginning. 3. A
alpha-thalassemia;hemoglobin H;Hb H;hemoglobin bart’s hydrop fetalis;Hb bart’s hydrops fetalis;BHFS 1. Introduction α-thalassemia occurs as a result of decreased or absent α-globin chain production and is characterized by a microcytic hypochromic anemia. Whereas affected patients with mild fo...
molecular testing by identifying the patients with a higher chance of having two or more α-globin genes mutated, we created this model. This is the first study to develop and validate a BLR model to predict the OR that a patient has two or more deletions related to α-thalassemia. ...