Alpha (α)-thalassemia represents a group of recessively inherited hemoglobin disorders marked by deficient or absent synthesis of 1 to all 4 of the α-globin genes. Inactivation of 3 α-globin genes – either by deletional or nondeletional mutations – results in hemoglobin H (Hb H) disease...
Treatment of alpha (0)-thalassemia (--SEA/--SEA)via serial fetal and post-natal transfusions:Can early fetal intervention improve outcomes?. Chmait RH,Baskin JL,Carson S,et al. Hematology . 2014Chmait RH, Baskin JL, Carson S, Randolph LM, Hamilton A (2015) Treatment of alpha...
The treatment for thalassemia varies depending on the type of thalassemia involved, but generally speaking, a person will need...
Thalassemia is the world’s most common hereditary disease, and is a paradigm of monogenic genetic diseases. Because of increased population mobility, the disease is found today throughout the world, even in places far from the tropical areas in which it arose. Therapy of thalassemia has in the...
We describe a rare set of monozygotic twins with coexistent sickle cell anemia and alpha-/alpha alpha thalassemia who have asynchronous painful crises of d... BR Amin,RM Bauersachs,HJ Meiselman,... - 《Hemoglobin》 被引量: 40发表: 1991年 δ0-Thalassemia in cis of βKnossos globin gene: ...
The article presents photographs of a girl who previously underwent a successful allogeneic bone marrow transplantation for severe Β-thalassemia. Prior to the transplantation, a liver biopsy showed severe iron overload, chronic active hepatitis, and bridging fibrosis. At a later date the child was ...
Thalassemia is a genetic disorder. Thalassemia is of two types-Alpha and Beta Thalassemia Read More Wilm's Tumor The cancer occurring in the kidneys is called nephroblastoma and it was discovered by a German doctor Max Wilms Read More
4.4.5 Intensity of Competitive Rivalry 5. MARKET SEGMENTATION 5.1 By Treatment Type 5.1.1 Blood Transfusions 5.1.2 Iron Chelation Therapy 5.1.3 Folic Acid Supplements 5.1.4 Others 5.2 By Disease Type 5.2.1 Alpha Thalassemia 5.2.2 Beta Thalassemia ...
beta-thalassemias are caused by nearly 300 mutations of the beta-globin gene, leading to a low or absent production of adult hemoglobin (HbA). Two major therapeutic approaches have recently been proposed: gene therapy and induction of fetal hemoglobin (HbF) with the objective of achieving clinica...
Effect of iron overload on the response to recombinant interferon-alfa treatment in transfusion-dependent patients with thalassemia major and chronic hepat... The purpose of this study was to determine whether interferon-alfa (IFN-alpha) therapy benefits patients with transfusion-dependent thalassemia ...