Tuckman J, Chu DS, Petrillo CR et al: Clinical trial of an alpha adrenergic recep- tor stimulating drug (clonidine) for treat- ment of spasticity in spinal cord injured patients. In Naftchi NE (ed): Spinal Cord Injury, Spectrum Pub, Jamaica, NY, 1982: 133-137...
Francisco Santolaria-Fernández, in Neuropathology of Drug Addictions and Substance Misuse, 2016 Liposoluble Vitamins As discussed below, the role of vitamin A or vitamin E deficiency on brain alterations and altered cognition has been well described for decades; more recently, the knowledge about ...
While such a difference was seen in the animal model of MI the authors stress that prolastin C was not given at the time of reperfusion as was the case in the mouse model [334] and that the later application time might have prevented an effect of the drug on the infarct size. None ...
I. Novel strategies for anti-aging drug discovery. Expert Opin. Drug Discov. 12, 955–966 (2017). Article CAS Google Scholar Maraka, S. & Kennel, K. A. Bisphosphonates for the prevention and treatment of osteoporosis. BMJ 351, h3783 (2015). Article CAS Google Scholar Barrett-Connor,...
resulting in a decrease in pressure. It accomplishes this by stimulating alpha type 2 receptors selectively in the eye with less effect on alpha type 2 receptors elsewhere in the body. It is the first drug of its class to be used for glaucoma. Brimonidine was approved by the FDA in 1996...
“Prodrugs” means any compound which releases an active parent drug according to Formula 1 in vivo when such prodrug is administered to a mammalian subject. Prodrugs of a compound of Formula 1 are prepared by modifying functional groups present in the compound of Formula 1 in such a way that...
It's obvious when the drug isn't working and, with known alternatives, I'd be surprised if anyone decided to stay in for a few months. Conversely, it's also easy to tell when it's working. Moreover, it's not like they're doing something completely new. It's definitely worth ...
Also, studies in aged mice suggest that oral supplementation of the autophagy‐stimulating disaccharide trehalose, restored vascular autophagy and ameliorated age‐related endothelial dysfunction70. On the basis of these results, we speculate that trehalose may disturb lysosome integrity and function, which...
List of Abbreviations α-gal Galactose-α (1,3)-galactose Anterior cruciate ligament bFGF Basic fibroblast growth factor BMP Bone morphogenetic protein Extracellular matrix ePTFE Extended polytetrafluoroethylene FDA US Food and Drug Administration PDGF-B Platelet-derived growth factor-B Polyetheret...
The study of baculoviruses, pathogens of larval lepidopteran insects, has been justified mainly by aims of improving their abilities to serve humanity—as pesticides, expression vectors, vaccine platforms, drug therapy vectors and more (Moscardi, 1999; Chuang et al., 2007; Airenne et al., 2013;...