Alprostadil (Caverject and Edex/Viridal) was the first and only drug approved for intracavernous treatment of ED [138]. Intracavernous alprostadil is most efficacious as a monotherapy at a dose of 5–40 μg (of note, 40 μg dose may be offered off-label in some European countries). An...
Sterile alpha motif (SAM) domain diversity. (a) The various locations of SAM domain proteins (represented by pentagons) and selected examples of their binding roles are shown. The illustration is meant as a general summary and, thus, in some instances ignores stoichiometry. For example, only ...
The structure of an mRNA molecule can be divided into several parts including a 5′ cap, 3′ poly (A) tail, 5′ and 3′ untranslated regions (5′- and 3′-UTRs), and an open reading frame (ORF). A number of these components can be altered to enhance the translatability or stabilit...
focusing on the virulence factors of cariogenic bacteriaS. mutans. It then summarizes the latest research progress, mechanism of action, application status, and challenges associated with the use of probiotics, prebiotics, synbiotics, and postbiotics in the prevention of dental caries. ...
drug composition for the treatment and prevention of the symptoms of heart failure, including an alpha - stimulating vasoconstrictor agent as the active substanceThis medicinal composition for the treatment and prevention of the symptoms of heart failure contains, by way of active principle, at least...
Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA), but it is hindered by rapid drug diffusion, thereby necessitating high-frequency injections. Hence, the development of a biofunctional hydrogel for impro
The description of the boundary-layer flow, based upon a triple-deck structure, shows how the presence of the hump generates an interaction between the inviscid region just outside the layer and the viscous region near the hump. The pressure force dominant in the boundary layer and the ...
Because of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been very well documented that—potentially severe
Although only 2% of those exposed to the drug developed PAH, the relative risk compared with unexposed individuals was 52:1 [117]. The use of fenfluramine derivatives was similarly associated with the development of PAH both in Europe and North America [118]. In a registry of 95 PAH ...
Tubulin is aglobular proteinproduced in all eukaryotic cells.1The term ‘tubulin’ was originally coined by Prof. Hideo Mohri, University of Tokyo, in 1968 as it is a constituent protein unit of microtubule. There are five distinct types of tubulins namely alpha, beta, gamma, delta, and eps...