ALPHA ADRENERGIC AGONIST DRUGS AND EMERGENCE FROM CARDIOPULMONARY BYPASSAn abstract is unavailable. This article is available as a PDF only.doi:10.1213/00000539-199002001-00380Smith, C EHiggins, T LKraenzler, E JStarr, N JCoyle, J PLicina, M G...
Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist at or near a target site, o
TABLE 4. Calculated Inhibition Constants for Various Drugs on Dopamine-Stimulated Cyclic AMP Production* Empty CellRabbit P2Goldfish Homogenate DrugKi (M)Ki (M) Fluphenazine 5.5 × 10−9 2× 10−9 Chlorpormazine 5× 10−8 − Thioridazine 1× l0−7 − (+) Butaclamol 4.5 × 10...
The present disclosure also relates to a method of treating one or more eye diseases or disorders in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a selective alpha2-adrenergic receptor agonist or an anticholinergic agent or a pharmaceutically ac...
The results suggested that a secretion-dependent residual aggregation could be supported by unbound internal receptors and the ability of drugs to block all of the pools of GPIIb/IIIa was a potential consideration for drugs that target this receptor. To attempt to integrate this finding with the ...
Studies on the antinociceptive action of α-agonist drugs and their interactions with opioid mechanisms 1 A modified abdominal constriction test, whereby the drugs used are injected intraperitoneally when the writhing response is maximal, has been used to stu... GA Bentley,SH Newton,J Starr - 《...
Tukey's post hoc analysis revealed that intra-NAc terazosin attenuated the locomotor activating effects of both drugs (Figures 2a and b). By contrast, there was only a main effect of treatment in the VTA for cocaine (F(1, 19) ¼ 30.4, po0.0001) and morphine (F(1, 23) ¼ 31.28,...
Appetite Regulation: ALPHA-MSH is also involved in the regulation of appetite. It acts on the hypothalamus to suppress appetite and promote satiety. This mechanism of action makes it a potential target for the development of anti-obesity drugs. Storage ...
The diblock copolymer PEG-b-PLA, an FDA-approved pharmaceuticalexcipient, has been widely used for the encapsulation and delivery ofanticancer drugsto treat various cancers over the past 20years[111]. PLA is a synthetic biocompatible and biodegradable polymer,while PEG is a biocompatible hydrophilic ...
Such an endophenotype-based diagnosis would lead to better treatment strategies with appropriate drugs for each disorder subtype. Conclusion In summary, we show that alpha-CaMKII heterozygous knockout mice have dysregulated behaviors, including a severe working memory deficit and an exaggerated infra- ...