In some embodiments, the alpha adrenergic receptor agonist comprises an alpha-2 adrenergic receptor agonist, which acts as an analgesic and/or anti-inflammatory agent. Examples of alpha-2 adrenergic receptor agonists useful in the present application include, but are in no way limited to L-norepine...
Partial alpha2-agonists are thought to lower blood pressure principally by stimulation of post-synaptic central nervous system alpha2-adrenoceptors. It is possible for some to have also a peripheral action, either by acting on the inhibitory presynaptic or as an antagonist at the postsynaptic alpha...
Agonists Concanavalin A (Con A) mimics the action of GSS[8]. α-Methyl-d-mannoside, a competitive inhibitor of Con A, completely inhibits the effect of Con A on follicle cells. However, α-methyl-D-mannoside has no effect on GSS action. ...
In a specific embodiment, Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides or polynucleotides of the invention, or agonists thereof, is administered to treat, prevent, prognose and/or diagnose common variable immunodeficiency. In a specific embodiment, Neutrokine-alpha and/or Neutrokine-alpha...
1 Guideline: Preoperative Medication Management Quick Guide for Preoperative Medication Management Medication Class Examples CONTINUE up to and including the day of surgery: Alpha1 Blockers Doxazosin, prazosin, tamsulosin Alpha2 Agonists Clonidine, guanfacine, methyldopa Antianxiety Ag...
Compounds 13, 24, and 28 are examples of submicromolar dual agonists with different α/γ EC 50 ratios that are selective against the δ-isoform. Analysis of the X-ray complex structure of PPARγ with the indole propionic acid 13 provides a rationalization for some of the observed SAR....
Agonists acting at benzodiazepine, gamma-aminobutyric acidA, barbiturate and neurosteroid recognition sites were studied for their attenuation of separation-... JA Vivian,H.M.T. Barros,A Manitiu,... - 《Journal of Pharmacology & Experimental Therapeutics》 被引量: 173发表: 1997年 Gamma-aminobuty...
The activity distributions for both the BG1 ER-luc and the ER-bla assays are shown in Figure 2 and Table 5. Approximately 5.6% of the library was identified as active agonists in the ER-bla assay, 86.6% as inactive and the rest of library (7.7%) were assigned one of the inconclusive ...
Examples include 1-hydroxymethyl-cyclopent-1-yl, 2-hydroxymethyl-cyclohex-2-yl and the like.“Heteroalkyl substituted heterocyclyl” means a heterocyclyl group wherein one, two, or three hydrogen atoms are replaced independently by heteroalkyl groups, with the understanding that the heteroalkyl ...
which are effective to act on or bind to alpha-2-adrenergic receptors and provide a therapeutic effect. As used herein, the term the term “alpha-2-adrenergic agonist component” means the agonists themselves and any and all precursors, salts and esters thereof, metabolites thereof and combinatio...