(Broaders, Cohen, Beaudette, Bachelder, & Fréchet, 2009) and have been used to encapsulateagonistsof TLR-7 showing a significant effect on the induction of pro-inflammatory cytokine expression by macrophagesin vitro(Bachelder et al., 2010). Furthermore, cross-linked dextranmicrospheres(CDMs) ...
1 Guideline: Preoperative Medication Management Quick Guide for Preoperative Medication Management Medication Class Examples CONTINUE up to and including the day of surgery: Alpha1 Blockers Doxazosin, prazosin, tamsulosin Alpha2 Agonists Clonidine, guanfacine, methyldopa Antianxiety Ag...
Partial alpha2-agonists are thought to lower blood pressure principally by stimulation of post-synaptic central nervous system alpha2-adrenoceptors. It is possible for some to have also a peripheral action, either by acting on the inhibitory presynaptic or as an antagonist at the postsynaptic alpha...
Alpha-fetoprotein (AFP), a serum glycoprotein, is expressed during embryonic development and the pathogenesis of liver cancer. It serves as a clinical tumor marker, function as a carcinogen, immune suppressor, and transport vehicle; but the detailed AFP
small volume, three month depot subcutaneous injection without a loading dose. VERU-100 is expected to immediately suppress testosterone with no testosterone surge upon initial or repeated administration, a concern that occurs with currently approved luteinizing hormone-releasing hormone agonists used for ...
Compositions comprising alpha-2-adrenergic agonists (agonists) and fatty acid components (FACs) are provided. The FACs employed in the present compositions may be effective in enhancing the pharmacokinetics of the agonists. For example, the FAC may enhance the therapeutic effect of the agonist. In ...
Synthesis and StructureActivity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists A series of novel, potent neuronal nicotinic acetylcholine receptor (nAChR) ligands derived from 3,6-diazabicyclo[3.2.0]heptane have been synthes...
Opioid agonists have been used throughout the history of mankind to alleviate pain. The best known compounds in this group are morphine, codeine, pethidine, mepiridine, tramadol, sufentanil and fentanyl. These compounds are still heavily used in pain treatment, amongst others in the treatment of ...
while α-2 adrenergic receptors are located postsynaptically as well as presynaptically, where they inhibit release of neurotransmitters. Agonists of α-2 adrenergic receptors currently are used clinically in the treatment of hypertension, glaucoma, spasticity, and attention-deficit disorder, in the supp...
Substituted 2-aminotetralin derivatives as selective alpha 2B agonists can be incorporated in a pharmaceutical composition and can be used in methods of treating an alpha 2B receptor mediated diseases or conditions. The compounds are represented by Formula 1: wherein R1=H, methyl, ethyl, propyl, ...