ALPHA ADRENERGIC AGONIST DRUGS AND EMERGENCE FROM CARDIOPULMONARY BYPASSAn abstract is unavailable. This article is available as a PDF only.doi:10.1213/00000539-199002001-00380Smith, C EHiggins, T LKraenzler, E JStarr, N JCoyle, J PLicina, M G...
A comparison of the beta-adrenoceptor agonist potency of labetalol with those of sympathomimetic drugs, and the role of alpha-receptors in pharmacological ... In the isolated atria, trachea and aorta of the guinea pig and in the heart-lung preparation (HLP) of the dog, labetalol was 3.6 ??
Release of different α-granule components may be differentially regulated depending on the agonist used. View chapterExplore book Platelet Secretion Robert Flaumenhaft, in Platelets (Third Edition), 2013 1 α-Granules in Inflammation Accumulating evidence demonstrates that platelets contribute to the ...
alpha-Melanocyte Stimulating Hormone amide is an endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-in...
Guanfacine, a noradrenergic alpha2a agonist, reduced tobacco smoking in a 4-week trial and in animal models has been shown to reduce cortical dopamine release, which is critically involved in the reinforcing effect of tobacco smoking. We measured amphetamine-induced extrastriatal dopamine release befor...
As reference we used the synthetic agonist WY14643. We analyzed gene expression 6 hours after oral gavage, thus we primarily studied the direct effects of PPARα activation. This time point was chosen because in a pilot experiment we found that after an oral fat load plasma triacylglycerol ...
The GLP-1 receptor is a member of family B with G protein-coupled receptors and is an important drug target for T2DM. This hormone docks with high affinity and is a full agonist with specific amino acid residues namely, Arg131, Lys136, Glu133, and Glu125 within the same region of the...
L-theanine administration results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion. Phytother. Res. 2013, 27, 1282–1287. [Google Scholar] [CrossRef] Adhikary, R.; Mandal, V. L-theanine: A potential multifaceted natural ...
ALPHAGAN® P (brimonidine tartrate ophthalmic solution) 0.1% or 0.15% is an alpha adrenergic receptor agonist indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. The recommended dose is one drop of ALPHAGAN® P (brimoni...
wherein the compounds of foimula 1 can be effectively used in combination with, for example, phenylpropanolamine, phentennine, diethylpropion, mazindol; fenfluramine, dexfenfluram-nine, phentiramine, 3 adrenoceptor agonist agents; sibutramine, gastrointestinal lipase inhibitors (such as orlistat), an...