Alpha-1-antitrypsin MZ phenotype and cryptogenic chronic liver disease in adults. Digestion 1983;27:100-104.Vecchio FM, Fabiano A, Orsini G, Ragusa D, Massi G: Alpha-1-antitrypsin MZ phenotype and cryptogenic chronic liver disease in adults. Digestion 27:100–104, 1983...
使用多变量线性回归、逆方差随机效应荟萃分析和最小绝对收缩和选择运算符 (LASSO) 回归,作者测试了 4,720 种蛋白质之间的关联,或结合蛋白质评分与肺气肿的关联,通过第 15 个百分位肺密度 (PD15) 或扩散能力 (DLCO) 测量不同的 AATD 基因型(Pi*ZZ、Pi*SZ、Pi*MZ)和非 AATD, PiMM COPD 受试者。使用受试...
Alpha-1-antitrypsin (Pi) phenotypes of 548 normal Finnish blood donors were determined by isoelectric focusing in polyacrylamide gel. The frequencies obtained (M, 93·3%; FM, 0·4%; GM, 0·2%; MS, 3·5%; MZ, 2·7%) differed from those reported earlier for a more restricted Finnish ...
A patient is described with micronodular cirrhosis, partial (heterozygous, MZ) deficiency of alpha-1-antitrypsin (AAT) and hepatocellular carcinoma. The pa... TH Marwick,PT Cooney,P Kerlin - 《Pathology》 被引量: 30发表: 1985年 Alpha-1 antitrypsin deficiency and the risk of hepatocellular car...
A case history of a 16-year-old boy with and an intermediate deficiency of (MZ phenotype) is presented. Previous reports have suggested that may be associated with the Z variant of antitrypsin and either a severe or intermediate antitrypsin deficiency. The present case is unusual because of the...
Pi type MZ had an a-1-antitrypsin concentration of 7.0 Trypsin inhibitory activity was first demonstrated in human mglliter at 7 wk postpartum and 4.1 rnglliter at 5 2 wk. It milk by Laskovski and Laskovski (13). Both A l A T and a-1- has been previously demonstrated that enhanced...
Subjects with alpha-1 antitrypsin deficiency who develop pulmonary disease are managed following general treatment guidelines, including disease management interventions. In addition, administration of intravenous infusions of alpha-1 proteinase inhibito
A patient is described with micronodular cirrhosis, partial (heterozygous, MZ) deficiency of alpha-1-antitrypsin (AAT) and hepatocellular carcinoma. The pa... TH Marwick,PT Cooney,P Kerlin - 《Pathology》 被引量: 30发表: 1985年 Alpha-1 antitrypsin deficiency and the risk of hepatocellular car...
Alpha1-antitrypsin [SEDA-31, 532; SEDA-33, 674] Adverse reactions to alpha1-antitrypsin concentrate as replacement therapy are rare. In an international randomized clinical trial, 29% of the patients had adverse reactions (0.004 drug-related adverse events per infusion) of which more than 90%...
Alpha-1-antitrypsin (A1AT) deficiency is the commonest genetic cause of liver disease in children and chronic obstructive lung disease in young adult smokers.The pathogenetic mechanisms are completely different. While low serum levels of A1AT cause reduced alveolar elasticity and subsequent emphysema,...