Alpha1-antitrypsin (AAT), a circulating single-chain glycoprotein is the most abundant serine proteinase inhibitor in human plasma. AAT is an acute phase protein, its levels increase rapidly to concentrations exceeding 50mM in response to inflammation, infection and malignant diseases. Since AAT is ...
Alpha-1-antitrypsin phenotypes were determined in 37 patients with rheumatoid arthritis and 40 patients with systemic lupus erythematosus. No significant increase in non-MM phenotypes was found. It appears that alpha-1-antitrypsin phenotypes neither predispose to the development nor enhance the severity ...
Purification and chemical compositions of human alpha1-antitrypsin of the MM type. FEBS Lett. 1973 Sep 1; 35 (1):79–82.Chan SK, Luby J, Wu YC: Purification and chemical compositions of human cq-antitrypsin of the MM type. FEBS Lett 35:79-82, 1973...
Alpha-1-antitrypsin (Pi) phenotypes have been determined in 40 patients suffering from Down's syndrome. Thirty-six of the patients were found to have a normal M phenotype, whereas two deficient phenotypes of the MS variety were observed. In addition, two M variants were noted. The ...
Alpha-1-antitrypsin concentration was ana- (9) demonstrated that intact proteases are absorbed from the lyzed by lostrum ( inm=m3u)naoneldecotfrompahtourreesmis ilink samples of human co- from mothers between intestinal tract of newborn rabbits. They postulated that the unopposed entry of ...
α1-antitrypsin (α1AT), a highly abundant circulating serine protease inhibitor, as SARS-CoV-2 entry inhibitor. We show that α1AT suppresses viral replication in cell lines and human airway epithelial cultures and that it binds and inactivates the serine protease TMPRSS2, which enzymatically ...
Pleural Disease/Pneumothorax PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: A recent series of case reports in children links Primary Spontaneous Pneumothorax (PSP) to alpha-1-antitrypsin (AAT) deficiency. However, epidemiological ...
1. Stoller JK, Aboussouan LS. a-1 antitrypsin deficiency. Lancet 2005; 365: 2225-36. 2. Stoller JK, Brantly M. The Challenge of Detecting Alpha-1 Antitrypsin Deficiency. COPD 2013; 10(S1): 26-34. [PubMed] [CrossRef] [Web of Science] 3. Mulgrew AT, Taggart CC, McElvaney MG. ...
Diagnosis of alpha-1-antitrypsin deficiency: An algorithm of quantification, genotyping, and phenotyping. Background: Laboratory testing in suspected [alpha]-1-antitrypsin (A1AT) deficiency involves analysis of A1AT concentrations and identification of specific... MR Snyder,JA Katzmann,ML Butz,... ...
DNA polymorphisms of alpha 1-antitrypsin gene region in patients with chronic obstructive pulmonary disease. Eur J Clin Invest 1990;20:1-7.Poller W, Meisen C, Olek K. DNA polymorphisms of the alpha 1-antitrypsin gene region in patients with chronic obstructive pulmonary disease. Eur J Clin ...