Cirrhosis and hepatocellular carcinoma in a patient with heterozygous (MZ) alpha-1- antitrypsin deficiency. Pathology 17, 649-652 (1985).Marwick TH, Cooney PT, Kerlin P (1985) Cirrhosis and hepatocellular carcinoma in a patient with heterozygous (MZ) alpha-1-antitrypsin deficiency. Pathology 17:...
点击蓝字 Arrowhead Pharmaceuticals前不久公布了正在进行的AROAAT2002研究(ARO-AAT,也称为TAK-999的开放标签2期临床研究)的额外中期临床数据,该公司的第二代研究性RNA干扰(RNAi)治疗药物,正在与武田制药有限公司共同开发,用于治疗与α-1抗胰蛋白酶缺乏症(alpha-1 an...
ABPA(allergic bronchopulmonary aspergillosis,变应性支气管肺曲霉菌病)、NTM(nontuberculous mycobacteria,非结核分枝杆菌)、CVID(common variable immunodeficiency disease,普通变异型免疫缺陷病)、GERD(gastroesophageal reflux disease ,胃食管反流病)、DPB(diffuse panbro...
Alpha-1 antitrypsin deficiency in liver disease in children: phenotypes, manifestations and prognosis Among 424 children with liver disease, 20 had alpha1-antitrypsin deficiency associated with protease inhibitor ZZ phenotype. This disorder manifested itself as cholestasis in early infancy in 19 children....
Kelly, J. KVasudev, K. SLee FI, Kelly JK, Vasudev KS (1983) Hepatic changes in a patient with alpha-l-antitrypsin deficiency (MZ phenotype). Portal tract elastosis and noncirrhotic portal hypertension. Arch Pathol Lab Med 107: 453–455...
A case of bile duct adenomas in association with heterozygous (MZ) deficiency of alpha 1-proteinase inhibitor (API) is presented. The salient features were the presence of large API-containing globules in the adenomatous tissue and only minimally, in granular form, in hepatocytes. alpha 1-Protein...
Pulmonary function in non- smoking subjects with alphal-antitrypsin deficiency (MZ phe- notype). Am J Med 1977; 62:93-8Gelb AF, Klein E, Lieberman J. Pulmonary function in nonsmoking subjects with alpha1-antitrypsin deficiency (MZ phenotype). Am J Med 1977; 82: 93-98....
alpha1 antitrypsin deficiencyThe ZZ genotype of alpha-1 antitrypsin deficiency (AATD) is associated with COPD regardless of smoking. Heterozygous MZ-AATD is recognised as a moderate deficiency state, increasing the risk of COPD only among smokers. The risk attributable to SZ-AATD remains debated. ...
Alpha-1-antitrypsin MZ phenotype and cryptogenic chronic liver disease in adults. Digestion 1983;27:100-104.Vecchio FM, Fabiano A, Orsini G, Ragusa D, Massi G: Alpha-1-antitrypsin MZ phenotype and cryptogenic chronic liver disease in adults. Digestion 27:100–104, 1983...
Alpha 1 antitrypsinLiver transplantLung diseaseAlpha-1 antitrypsin, also known as alpha1 proteinase inhibitor, is a protein 90% synthesized by hepatocytes. Alpha-1 antitrypsin deficiency should be suspected if patients have unexplained emphysema or liver disease in the absence of others recognized ...