Lawley, P. D. : Mechanism of action of alkylating agents: comparison with other cytotoxic, mutagenic and carcinogenic agents. In: Molekulare Biologie des malignen Wachstums, p. 126–141. See also Diskussion ibid., p. 150–155. Berlin-Heidelberg-New York: Springer 1966....
1、生物烷化剂(bioalkylating agents)(生物烷化剂(生物烷化剂)生物烷化剂(生物烷化剂)也称烷化剂,抗肿瘤药中使用最早的一类。1、作用机理:在体内形成缺电子活泼中间体,及其它有活泼亲电基团的化合物,与生物大分子(DNA,RNA或酶)中含有丰富电子的基团,亲电共价结合,使大分子失活,阻碍其正常生理功能。2、缺点:...
Mechanism of action of drugs. Alkylating agents act by cross-linking strands of DNA, particularly at the N-7 position of guanine. They are nonspecific for cell cycle phase and are thus active during most parts of the cell cycle. Alkylating agents in the classic family include nitrogen...
Temozolomide is an imidazotetrazine with a mechanism of action and efficacy similar to dacarbazine (DTIC). However, it differs from DTIC in that it can be taken orally, degrades spontaneously to an active metabolite and penetrates the blood-brain barrier. It is well tolerated, making it a suit...
S23906-1 stands as the most promising lead of a medicinal chemistry program aimed at discovering novel antitumor drugs based on the acronycine skeleton. 展开 关键词: dna alkylation mechanism of action drug-dna recognition anticancer agent
DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens In contrast, the alkylating agents 4-nitroquinoline-1-oxide, mitomycin C, methylnitrosourea, ethylnitrosourea, methylmethane sulfonate and ethylmethane ... SM Galloway...
Balancing repair and tolerance of DNA damage caused by alkylating agents Nat. Rev. Cancer, 12 (2012), pp. 104-120 Google Scholar [9] M.T. Hayes, J. Bartley, P.G. Parsons, G.K. Eaglesham, A.S. Prakash Mechanism of action of fotemustine, a new chloroethylnitrosourea anticancer agent...
This treatment induced durable responses in up to 35% of patients, and hence is superior to many commonly used toxic combination chemotherapies. The mechanism of action, although not well characterized, is thought to be mediated through protection of the cellular immune process, as well as organ...
Antitumour alkylating agents: cytotoxic action and organ toxicity. Connors TA. TA Connors - 《Iarc Sci Publ》 被引量: 6发表: 1986年 [Synthesis, cytostatic activity and mechanism of action of N-glycosylhalomethylazoles. A new class of alkylating agents] A model to produce a new type of ...
Mechanism same as N-mustard: Nitrosurea. Very lipid-soluble: Tx of brain tumors 4. Cis-Platin (solid tumors; testicular and lung)Platinum drug; do not have an alkyl group. Extensively used. Mechanism: similar to other Alkylating Agents. Cross-links DNA (esp intrastand) forming Pt-DNA ...