Many immunohistochemistry (IHC) assays use alkaline phosphatase (AP) to detect in-vitro cancers. IHC assays use antibody-enzyme conjugates that pair with primary antibodies specific to antigens on the surface of cancer cells. As the catalyzing enzyme, AP removes a phosphate from a substrate ...
Serum levels of alkaline phosphatase (AP) have been used in the clinical evaluation of numerous diseases, including malignancies, for half a century. The aberrant expression of AP genes in cancer cells has led to the suggestion that APs are oncofetal proteins and thus, could be involved in tu...
Abstract: the objective to investigate serum alpha-fetoprotein (AFP), alkaline phosphatase (ALP), algae glucoside enzyme α-l-rocks (AFU) and gamma-l-acyl transferase (GGT) on primary liver cancer (PHC) of diagnostic value. Combined detection of 83 cases with primary liver cancer and 50 healt...
Serum alkaline phosphatase level as a prognostic tool in colorectal cancer: a study of 105 patients. J Appl Res 2005; 5:88-95.Saif MW, Alexander D, Wicox CM. Serum Alkaline Phosphatase Level as a Prognostic Tool in Colorectal Cancer: A Study of 105 patients. J Appl Res. 2005;5(1):...
Respiratory Medicine Case Reports Volume 13, 2014, Pages 51-53Case reportAlkaline phosphatase flare phenomenon following epidermal growth factor receptor-tyrosine kinase inhibitor treatment of non-small cell lung cancer: Report of a case and case review Author links open overlay panelYuko Yasuda...
L., Immunology and biochemistry of Regan isoenzyme of alkaline phosphatase in human cancer, Nature (London), 219, 697, 1968.Fishman WH, Inglis NR, Green S, Anstiss CL, Ghosh NK, Reif AE, Rustigan R, Krant MJ, Stolbach LL. Immunology and biochemistry of Regan isoenzyme of alkaline ...
Association of alkaline phosphatase with clinical outcomes in chemotherapy-naive patients with metastatic castration-resistant prostate cancer: results from COU-AA... P Mainwaring,EY Yu,A Londhe,... - Scientific Meeting of the 被引量: 3发表: 2014年 加载更多来源...
We report an 87-year-old woman who was admitted to our hospital due to anemia and extremely elevated serum alkaline phosphatase (ALP) levels. We diagnosed advanced gastric cancer with disseminated carcinomatosis of the bone marrow and multiple bone metastasis. She was immediately treated with low-...
The mechanism for calcifications in breast cancer is not completely known. Understanding this mechanism will improve diagnostic accuracy. Herein, we demonstrated that calcifications occur and that alkaline phosphatase enzyme activity increases in MDA-MB-231 cells cultured using an osteogenic cocktail-...
Also, administration of protein compositions may be part of a more complex cancer therapy. One of the human proteins used in an alternative embodiment of the invention is placental alkaline phosphatase (PALP) a member of the alkaline phosphatase family. In one embodiment, the invention provides ...