Many immunohistochemistry (IHC) assays use alkaline phosphatase (AP) to detect in-vitro cancers. IHC assays use antibody-enzyme conjugates that pair with primary antibodies specific to antigens on the surface of cancer cells. As the catalyzing enzyme, AP removes a phosphate from a substrate ...
When abnormal bone tissue is being formed by cancer cells, levels ofalkaline phosphatase increase. Therefore, high levels of this enzyme could suggest that a patient has bone metastasis. However, a high level of the enzyme is also found in growing children and in people with fractured bones tha...
Serum levels of alkaline phosphatase (AP) have been used in the clinical evaluation of numerous diseases, including malignancies, for half a century. The aberrant expression of AP genes in cancer cells has led to the suggestion that APs are oncofetal proteins and thus, could be involved in tu...
Alkaline phosphatase may go up by as much as three times when you’re pregnant. If your blood test shows levels that are higher than expected, your doctor may check your levels more often to make sure your placenta is healthy. If your ALP level is very high, your doctor may have you t...
Alkaline phosphatase (AP) is composed of several isoenzymes that can hydrolyze organic phosphatase ester bonds in an alkaline medium, giving rise to an organic radical and inorganic phosphate. From: Biomarkers in Toxicology (Second Edition), 2019 ...
alkaline phosphatase, colon cancer, rectal cancer, liver metastasisBackgroundSerum alkaline phosphotase (ALP) levels are frequently elevated in patients with metastatic colorectal cancer (CRC). However, the significance of ALP in terms of detecting hepatic metastasis or prognosis is not well established...
Abstract: the objective to investigate serum alpha-fetoprotein (AFP), alkaline phosphatase (ALP), algae glucoside enzyme α-l-rocks (AFU) and gamma-l-acyl transferase (GGT) on primary liver cancer (PHC) of diagnostic value. Combined detection of 83 cases with primary liver cancer and 50 healt...
The four known isozymes of the human alkaline phosphatase (ALP) were detected by isoelectric focusing in extracts of various types of germ cell tumors, three related cell lines, and their precancerous elements (atypical germ cells). In seminoma, placental alkaline phosphatase (PLAP) and germ cel...
Transient very high levels of ALP, reaching up to 30 times the upper reference limit, have been documented in children. However, the clinical significance of this finding is unknown. This phenomenon has been termed "transient hyperphosphatasemia" and may involve either the bone or liver isoenzyme...
ALKALINE PHOSPHATASE ASSAY 优质文献 相似文献Assessment of the serum levels of bone alkaline phosphatase with a new immunoradiometric assay in patients with metabolic bone disease. Garnero,P,Delmas,... - 《Journal of Clinical Endocrinology & Metabolism》 ...