Many immunohistochemistry (IHC) assays use alkaline phosphatase (AP) to detect in-vitro cancers. IHC assays use antibody-enzyme conjugates that pair with primary antibodies specific to antigens on the surface of cancer cells. As the catalyzing enzyme, AP removes a phosphate from a substrate ...
Alkaline phosphatase (AP) is composed of several isoenzymes that can hydrolyze organic phosphatase ester bonds in an alkaline medium, giving rise to an organic radical and inorganic phosphate. From: Biomarkers in Toxicology (Second Edition), 2019 ...
Serum levels of alkaline phosphatase (AP) have been used in the clinical evaluation of numerous diseases, including malignancies, for half a century. The aberrant expression of AP genes in cancer cells has led to the suggestion that APs are oncofetal proteins and thus, could be involved in tu...
Abstract: the objective to investigate serum alpha-fetoprotein (AFP), alkaline phosphatase (ALP), algae glucoside enzyme α-l-rocks (AFU) and gamma-l-acyl transferase (GGT) on primary liver cancer (PHC) of diagnostic value. Combined detection of 83 cases with primary liver cancer and 50 healt...
Does high alkaline phosphatase mean cancer? When abnormal bone tissue is being formed by cancer cells, levels ofalkaline phosphatase increase. Therefore, high levels of this enzyme could suggest that a patient has bone metastasis. However, a high level of the enzyme is also found in growing chil...
The four known isozymes of the human alkaline phosphatase (ALP) were detected by isoelectric focusing in extracts of various types of germ cell tumors, three related cell lines, and their precancerous elements (atypical germ cells). In seminoma, placental alkaline phosphatase (PLAP) and germ cel...
- 《Cancer》 被引量: 491发表: 1981年 Bone marrow necrosis: clinicopathologic analysis of 20 cases and review of the literature. leukopenia, thrombocytopenia, and high LDH and alkaline phosphatase levels were detected in the majority of the cases, as was also seen in other series. ... S Pay...
Serum alkaline phosphatase level as a prognostic tool in colorectal cancer: a study of 105 patients. J Appl Res 2005; 5:88-95.Saif MW, Alexander D, Wicox CM. Serum Alkaline Phosphatase Level as a Prognostic Tool in Colorectal Cancer: A Study of 105 patients. J Appl Res. 2005;5(1):...
Association of alkaline phosphatase with clinical outcomes in chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC): results from COU-... Association of alkaline phosphatase with clinical outcomes in chemotherapy-naive patients with metastatic castration-resistant prostate cancer: results fr...
The probe was expected to be promising tool for practical application in disease diagnosis on the roles of ALP in disease. Graphical abstract A promising near-infrared fluorescent probe for turn-on trapping of ALP activity in living cancer cells, tumor tissues and living tumor xenograft in nude ...