alkaline phosphatase, bloodcolonic neoplasmsenzyme testsneoplasms, enzymologyrectal neoplasmsSerum alkaline phosphatase is often elevated in patients with colorectal cancer without liver metastases. The enzyme activity in tissue homogenates was 2-3 times higher in tumours than in the surrounding mucosa in ...
This results in a growing, critical effect on both social and economic aspects of society. Fortunately, researchers are developing simple, accurate tests for cancer detection. Many immunohistochemistry (IHC) assays use alkaline phosphatase (AP) to detect in-vitro cancers. IHC assays use antibody-...
When abnormal bone tissue is being formed by cancer cells, levels ofalkaline phosphatase increase. Therefore, high levels of this enzyme could suggest that a patient has bone metastasis. However, a high level of the enzyme is also found in growing children and in people with fractured bones tha...
Serum levels of alkaline phosphatase (AP) have been used in the clinical evaluation of numerous diseases, including malignancies, for half a century. The aberrant expression of AP genes in cancer cells has led to the suggestion that APs are oncofetal proteins and thus, could be involved in tu...
In this study, a label-free sensing method based on a functionalized nanopipette is proposed for detection of alkaline phosphatase (ALP) activity. This method is based on the unique charge transport properties of nanopores in which the ionic current can be modulated by variation in the charge on...
the elevation is likely due to liver phosphatase. These conclusions are drawn from the observation that the 4 major fractions exhibit varying heat stabilities, with placental ALP being the most heat-resistant, followed by intestinal, liver, and bone fractions in decreasing order of heat stability. ...
Few prognostic factors have been identified and successfully replicated for patients with high-risk nonmetastatic castration-resistant prostate cancer (nmCRPC). However, a new report has shown that alkaline phosphatase velocity (APV) is an independent predictor of bone-metastasis-free survival and ...
Identification of bone and liver metastases from breast cancer by measurement of plasma alkaline phosphatase isoenzyme activity. Isoenzyme determination provided additional information that would have changed patient management in five of 20 patients who were monitored serially. Measurement of alkaline phosphata...
Alkaline phosphatase (AP) is composed of several isoenzymes that can hydrolyze organic phosphatase ester bonds in an alkaline medium, giving rise to an organic radical and inorganic phosphate. From: Biomarkers in Toxicology (Second Edition), 2019 ...
The four known isozymes of the human alkaline phosphatase (ALP) were detected by isoelectric focusing in extracts of various types of germ cell tumors, three related cell lines, and their precancerous elements (atypical germ cells). In seminoma, placental alkaline phosphatase (PLAP) and germ cel...