Almost 30 years after discovery of a link between alcohol consumption and certain forms of cancer, scientists are reporting the first evidence from research on people explaining how the popular beverage may be carcinogenic. The results, which have special implications for hundreds of millions of peopl...
The evidence for the association between alcohol and other cancers is inconclusive. Because of the high prevalence of ALDH2*2 allele among East Asian populations, East Asians may be more susceptible to the carcinogenic effect of alcohol, with most evidence coming from studies of esophageal cancer ...
Almost 30 years after discovery of a link between alcohol consumption and certain forms of cancer, scientists are reporting the first evidence from research on people explaining how the popular beverage may be carcinogenic. The results, which have special implications for hundreds of millions of ...
By using specific knockout mice, Rusyn and colleagues clearly showed that CYP2E1, but not NADPH oxidase, is important in promoting alcohol-mediated DNA damage (Bradford et al., 2005). The important role of CYP2E1 in producing carcinogenic etheno-DNA lesions was consistently reported in the ...
In the personal care industry, benzyl alcohol is used as a fragrance ingredient and a solvent in cosmetic formulations. It can also act as a preservative, preventing the growth of microorganisms in products. Mechanism of action In pharmaceutical applications, benzyl alcohol acts as a solvent, ...
For example, in contrast to leukemic cells, human primary T lymphocytes or monocytes are rather resistant to farnesol-induced apoptosis. The mechanism underlying this differential sensitivity is not yet understood. Farnesol inhibits cell proliferation with IC50s that range from 25 to 250 μM. ...
an elevated level of estrogen by testosterone conversion; an increased level of insulin-like growth factors from the liver due to alcohol consumption93,94; and disruption of folate metabolism95. Also, acetaldehyde, derived from the metabolism of ethanol, is a carcinogenic metabolite that causes form...
reactions after alcohol consumption; for instance, theALDH2genetic variant is prevalent only in East Asians and is associated with an inability to metabolize a carcinogenic alcohol metabolite, acetaldehyde, into acetate39. Moreover, differences in ethnicity, dietary intake, exposure to environmental ...
Docosanol (12; behenyl alcohol) is a saturated primary alcohol with 22 carbon atoms, capable of inhibiting a wide range of viruses, including HSV, HCMV, and VZV. Though the mechanism of docosanol is debatable, it is believed that it acts by inhibiting viral entry into the host cells by in...
TheALDH2is the major player in the metabolism of alcohol-derived acetaldehyde, a carcinogenic whose accumulation is detrimental to cellular processes. Individuals with mutant ALDH2 (ALDH2*2) have been identified to manifest a range of diseases and cancers, including liver andhead and neck cancers...