Due to its high reactivity with DNA, acetaldehyde can potentially form DNA adducts, altering its physical properties and interfering with DNA synthesis and repair, which is one of the major contributing factors in its carcinogenic mechanism. With a further understanding of MTHFR polymorphisms, ...
Phenylethanols: tyrosol, salidroside, viridoside (antioxidant, stimulant, adaptogenic, antiviral, anti-inflammatory, anticarcinogenic, antiapoptotic, antifibtrotic) ■ Phenolic acids: gallic acid ■ Phenylpropanoids (antioxidant, antimutagenic, antitumor, antimicrobial): chlorogenic acid (antioxidant), hydroxy...
By using specific knockout mice, Rusyn and colleagues clearly showed that CYP2E1, but not NADPH oxidase, is important in promoting alcohol-mediated DNA damage (Bradford et al., 2005). The important role of CYP2E1 in producing carcinogenic etheno-DNA lesions was consistently reported in the ...
The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirmed metabolic pathway of HMF and FFA in mice. It is known that orthologous SULT forms substantially differ in substrate specificity and ...
Goblet cells secrete an important component, mucin; that constitutes another major physical barrier known as the mucus layer, offering protection against luminal pathogens [53]. The mucus layer is found throughout the digestive tract including the stomach, the small intestine, and the colon; however...
Numerous anticarcinogenic properties of the polyphenols have been proposed [84]. A potentially interesting finding in the current study is the association between higher recent intakes of wine with decreased risk of clear cell ovarian carcinoma. The association persisted following exclusion of the ...
an elevated level of estrogen by testosterone conversion; an increased level of insulin-like growth factors from the liver due to alcohol consumption93,94; and disruption of folate metabolism95. Also, acetaldehyde, derived from the metabolism of ethanol, is a carcinogenic metabolite that causes form...
You see, ethanol (alcohol) is essentially a toxin (the dose makes the poison, wouldn’t ya say?) that needs to be metabolized properly in the body in order to be eliminated. The most common pathway looks like this: Alcohol is converted into acetaldehyde by an enzyme known as al...
TheALDH2is the major player in the metabolism of alcohol-derived acetaldehyde, a carcinogenic whose accumulation is detrimental to cellular processes. Individuals with mutant ALDH2 (ALDH2*2) have been identified to manifest a range of diseases and cancers, including liver andhead and neck cancers...
Various other phytochemicals found in plants also have antitumor or anticarcinogenic effects. Isoprenoids are nonnutritive dietary phytochemicals found in the essential oils of citrus fruits, cherry, spearmint, dill, caraway, and other plants. Bioactive isoprenoids include limonene, perillyl alcohol, gera...