Merits and demerits of alcoholic beverage intake have been long explored because of its benefit for cardiovascular disease (Corrao et al, 2000; Fillmore et al, 2007; Ronksley et al, 2011) or carcinogenic effect (Kan et al, 2011). An International Review panel, sponsored by the World Cancer...
doi:10.1001/jamanetworkopen.2023.28328 Key Points Question What is the prevalence of current alcohol consumption and of risky alcohol consumption among cancer survivors in the US? Findings In this cross-sectional study of 15 199 adults with a cancer diagnosis from the All of Us Research Program...
For many cancers, a key mechanism is thought to be the conversion of ethanol by alcohol hydrogenase into carcinogenic acetaldehyde [1]. For other cancers, such as breast cancer, it has been hypothesised that greater alcohol intake increases risk by elevating levels of certain sex hormones [3,...
Primary liver cancer is also associated with alcohol consumption, probably by a less direct action; the importance of the impact of alcohol on primary liver cancer is probably underestimated. Animal experiments have not shown that ethanol alone has a carcinogenic effect, and the mechanisms by which...
TheALDH2is the major player in the metabolism of alcohol-derived acetaldehyde, a carcinogenic whose accumulation is detrimental to cellular processes. Individuals with mutant ALDH2 (ALDH2*2) have been identified to manifest a range of diseases and cancers, including liver andhead and neck cancers...
Phenylethanols: tyrosol, salidroside, viridoside (antioxidant, stimulant, adaptogenic, antiviral, anti-inflammatory, anticarcinogenic, antiapoptotic, antifibtrotic) ■ Phenolic acids: gallic acid ■ Phenylpropanoids (antioxidant, antimutagenic, antitumor, antimicrobial): chlorogenic acid (antioxidant), hydroxy...
For many cancers, a key mechanism is thought to be the conversion of ethanol by alcohol hydrogenase into carcinogenic acetaldehyde [1]. For other cancers, such as breast cancer, it has been hypothesised that greater alcohol intake increases risk by elevating levels of certain sex hormones [3,...
International Agency for Research on Cancer (2010) Alcohol Consumption and Ethyl Carbamate - IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 96, International Agency for Research on Cancer: Lyon. Kabat GC, Park Y, Hollenbeck AR, Schatzkin A, Rohan TE (2011) ...
This finding suggests that repeated alcohol consumption events even at lower amounts of alcohol may have a greater carcinogenic effect on GI organs than the consumption of larger amounts of alcohol at a lower frequency. There is also very limited information on the mechanism by which frequency of...
By using specific knockout mice, Rusyn and colleagues clearly showed that CYP2E1, but not NADPH oxidase, is important in promoting alcohol-mediated DNA damage (Bradford et al., 2005). The important role of CYP2E1 in producing carcinogenic etheno-DNA lesions was consistently reported in the ...