Abstract Importance Alcohol consumption is associated with adverse oncologic and treatment outcomes among individuals with a diagnosis of cancer. As a key modifiable behavioral factor, alcohol consumption patterns among cancer survivors, especially during treatment, remain underexplored in the United States. ...
Almost 30 years after discovery of a link between alcohol consumption and certain forms of cancer, scientists are reporting the first evidence from research on people explaining how the popular beverage may be carcinogenic. The results, which have special implications for hundreds of millions of peopl...
The inverse associa- tions were consistent across specific alcoholic beverages, suggest- ing that ethanol per se is most likely the responsible factor. We also found that alcoholic beverage intake lowered risk of renal cell cancer for both men and women. Notably, our spline analysis showed that ...
Anticoagulant drugs that inhibitthrombus formationand inheritedFactor X deficiency(a form of hemophilia) It is probably safe to infer that in addition to the many known genetic diseases for which there are phenocopies, there must be a large number of cryptic genetic errors whose phenocopies can ne...
Alcohol, in general, has been reported to reduce cellular proliferation by influencing the insulin and insulin-like growth factor (IGF) pathways [73, 74], and these pathways have been implicated in the early development and prognosis of clear cell carcinoma types [75–78]. Because obesity is ...
By using specific knockout mice, Rusyn and colleagues clearly showed that CYP2E1, but not NADPH oxidase, is important in promoting alcohol-mediated DNA damage (Bradford et al., 2005). The important role of CYP2E1 in producing carcinogenic etheno-DNA lesions was consistently reported in the ...
Abstract Importance Although total alcohol consumption is a known risk factor for gastrointestinal (GI) cancers, few studies have attempted to assess the pattern of alcohol drinking in association with GI cancers. Objective To evaluate the relative association of the frequency of drinking vs the amount...
Primary liver cancer is also associated with alcohol consumption, prob ably by a less direct action; the importance of the impact of alcohol on primary liver cancer is probably underestimated. Animal experiments have not shown that ethanol alone has a carcinogenic effect, and the mechanisms by ...
Additionally, acetaldehyde, a by-product of ethanol, is known to have direct mutagenic or carcinogenic effects (Poschl and Seitz, 2004). It may also induce skin inflammation, which may interfere with keratinocyte DNA synthesis and repair, which can promote skin carcinogenesis (Coutelle et al., ...
(IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 96). Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Bouvard V et al. Carcinogenicity of alcoholic beverages. Lancet Oncol 2007; 8: 292–293. Article Google Scholar Rota M, Scotti L, Turati F, Trama...