doi:10.1001/jamanetworkopen.2023.28328 Key Points Question What is the prevalence of current alcohol consumption and of risky alcohol consumption among cancer survivors in the US? Findings In this cross-sectional study of 15 199 adults with a cancer diagnosis from the All of Us Research Program...
Even in those cases where the association of alcohol with a specific cancer is well established, the mechanisms underlying such associations are still poorly understood [2]. For many cancers, a key mechanism is thought to be the conversion of ethanol by alcohol hydrogenase into carcinogenic acetal...
Even in those cases where the association of alcohol with a specific cancer is well established, the mechanisms underlying such associations are still poorly understood [2]. For many cancers, a key mechanism is thought to be the conversion of ethanol by alcohol hydrogenase into carcinogenic acetal...
TheALDH2is the major player in the metabolism of alcohol-derived acetaldehyde, a carcinogenic whose accumulation is detrimental to cellular processes. Individuals with mutant ALDH2 (ALDH2*2) have been identified to manifest a range of diseases and cancers, including liver andhead and neck cancers...
The important role of CYP2E1 in producing carcinogenic etheno-DNA lesions was consistently reported in the experimental model and alcoholic individuals (Wang et al., 2009). In addition, abnormal retinoic acid metabolism is considered important in fetal alcohol syndrome or effects due to its ...
Numerous anticarcinogenic properties of the polyphenols have been proposed [84]. A potentially interesting finding in the current study is the association between higher recent intakes of wine with decreased risk of clear cell ovarian carcinoma. The association persisted following exclusion of the ...
Is ethoxylate alcohol harmful? Alcohol ethoxylates are not observed to be mutagenic, carcinogenic, or skin sensitizers, nor cause reproductive or developmental effects. One byproduct of ethoxylation is 1,4-dioxane, a possible human carcinogen. Undiluted AEs can cause dermal or eye irritation. ...
Although the toxic and carcinogenic natures of benzene have been known for some time, the 10鈥塸pm regulation governing human exposure to it as a vapor or ... - 《Journal of Safety Research》 被引量: 0发表: 1984年 Alcohol fuels (citations from the NTIS data base). Report for 1964-Jul...
reactions after alcohol consumption; for instance, theALDH2genetic variant is prevalent only in East Asians and is associated with an inability to metabolize a carcinogenic alcohol metabolite, acetaldehyde, into acetate39. Moreover, differences in ethnicity, dietary intake, exposure to environmental ...
and colorectal cancer. The evidence for the association between alcohol and other cancers is inconclusive. Because of the high prevalence ofALDH2*2allele among East Asian populations, East Asians may be more susceptible to the carcinogenic effect of alcohol, with most evidence coming from studies of...