Breast Cancer Res TreatYu H, Bharaj B, Vassilikos EJ, Giai M, Diamandis EP. Shorter CAG repeat length in the androgen receptor gene is associated with more aggressive forms of breast cancer. Breast Cancer Res Treat. 2000; 59 :153–161....
The identification of biomarkers that distinguish between aggressive and indolent forms of prostate cancer (PCa) is crucial for diagnosis and treatment. In... - 《Journal of Clinical Investigation》 被引量: 0发表: 2009年 Validation of reported GLT6D1 (rs1537415), IL10 (rs6667202), and ANRIL...
also known as squalene monooxygenase)14, a rate-limiting enzyme of cholesterol synthesis and known cancer-related gene in PCa, whose expression is correlated with poor prognosis and survival in this entity15,16. We confirm that high SQLE protein expression is correlated with poor outcome in PCa....
High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients Article MicroRNAs as biomarkers for prostate cancer prognosis: a systematic review and a systematic reanalysis of public data ArticleOpen access12 January 2022 Urinary exosome microRNA signat...
By eliminating NIHCOLE, cancer cells treated with radiotherapy die more easily. However, the molecular mechanism by which NIHCOLE facilitates the repair of DNA breaks was not known. The paper just published in Cell Reports explains this: NIHCOLE forms a bridge that binds the broken DNA...
Centrosome amplification (CA) is highly prevalent in cancer [1, 2], and is strongly associated with tumor progression and worse prognosis in a variety of different cancers, e.g., breast, prostate, ovarian and lung [2]. CA is associated with several oncogenic phenotypes, such as aneuploidy, ...
This histologically heterogeneous group of cancers, including different forms of the neuroendocrine carcinoma of the prostate, share a common clinical course associated with a poor response to androgen deprivation treatment and fatal prognosis. Currently, the most commonly used terms are aggressive variant...
Downregulation of miR-221 was negatively correlated with the expression of the proto-oncogen c-kit in primary carcinoma. In a large study cohort, the prostate-specific oncomir miR-221 was progressively downregulated in aggressive forms of PCa. Downregulation of miR-221 was associated with ...
The exogenous hypoxia marker pimonidazole is a 2-nitroimidazole compound, which forms covalent bonds with cellular macromolecules at oxygen levels below 1.3% (Gross et al, 1995) and visualises poorly oxygenated regions in histological sections from tumours (Kizaka-Kondoh and Konse-Nagasawa, 2009). ...
Overview of the steroidogenic pathways thought to be functional in the breast. The classical steroid receptors thought to govern breast cancer prognosis are the oestrogen receptor alpha (ERα) and the Progesterone Receptor (PR). In addition to these the Human Epidermal Growth Factor Receptor 2 (HER...