Background: Although the overall 5-year survival rate for prostate cancer (PCa) is relatively high, there are substantial differences in survival by stage at diagnosis. In contrast to men diagnosed with localize
Prostate cancer is the second leading cause of cancer deaths among men in the United States, and it disproportionally affects Black men, who are twice as likely to be diagnosed with and die of the disease. Catching this cancer in its early stages is key, as the five-year survival rate for...
Patients so treated exhibited a 5-year survival rate of 49 per cent, far greater than the average survival rates usually quoted. Radiation therapy had been used primarily in conjunction with other treatment measures, and multiple drug chemotherapy is now being used in patients who demonstrate ...
The role of dysregulation of mRNA alternative splicing (AS) in the development and progression of solid tumors remains to be defined. Here we describe the first comprehensive AS landscape in the spectrum of human prostate cancer (PCa) evolution. We find
Consistent with the known upregula- tion of MYC in human prostate cancer [33, 34], the IHC staining quantification showed robust MYC expression which correlated with CRIPTO expression (**p = 0.0098) (Fig. 5g). Notably, Kaplan- Meyer survival curve showed a correlation with PSA progression ...
Prostate cancer risk factors include age, family history of the disease, and race/ethnicity. African American men have the highest rate of prostate cancer mortality in the world. This marked racial disparity may be the result of differences in access to and attitudes about screening and treatment...
Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway. Here, we show that squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis pathway, is overexpressed in advanced PCa and its expression correlates with poor survival. SQLE expression is controlled by...
Non-aggressive prostate cancer is a type of prostate cancer that is very slow-growing (and often localized) and is not an immediate risk to the... Learn more about this topic: Male Reproductive Disorder: Prostate Cancer from Chapter 18/ Lesson 25 ...
Highly aggressive cancers include PDAC, NSCLC, CRC, hepatocellular carcinoma (HCC) or liver cancer, breast cancer, prostate cancer, and brain tumors, such as glioblastoma. Neuroblastoma is an example of a highly aggressive solid tumor in early childhood. Below we consider their oncogenic expression ...
Radical prostatectomy or watchful waiting in early prostate cancer. N Engl J Med. 2014;370(10):932-942.PubMedGoogle ScholarCrossref 2. Bolla M, Gonzalez D, Warde P, et al. Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin. N Engl ...