SIRT5Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men worldwide. Among patients who developed advanced PCa, 80% suffered from bone metastasis, with a sharp drop in the survival rate. Despite great efforts, the detail of the mechanisms underlying castration-resistant PCa...
and it disproportionally affects Black men, who are twice as likely to be diagnosed with and die of the disease. Catching this cancer in its early stages is key, as the five-year survival rate for an early-stage prostate cancer diagnosis is 98%, versus 31% for later-stage diag...
formulated by Aparicio et al.: 1) Histological evidence of small cell neuroendocrine prostate cancer (NEPC); 2) presence of exclusively visceral metastases; 3) predominant lytic bone metastases; 4) bulky lymphadenopathy or bulky high-grade
Prostate cancer (PC) is the second most common malignancy in men worldwide. Its incidence and mortality increase with ag e , reaching nearly 60% and 55% in men over the age of 65 adequately. The 5-year survival rate slightly varies worldwide and is around 98% in the USA. PS A is ...
African American men are about 1.5 times more likely to develop prostate cancer and about 2.5 times more likely to die from prostate cancer. However, there's no known cause of increased rate of morbidity and mortality in these population... S Khan,TR Stiff,J Simpson,... - 《Cancer Epidemi...
Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway. Here, we show that squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis pathway, is overexpressed in advanced PCa and its expression correlates with poor survival. SQLE expression is controlled by...
The role of dysregulation of mRNA alternative splicing (AS) in the development and progression of solid tumors remains to be defined. Here we describe the first comprehensive AS landscape in the spectrum of human prostate cancer (PCa) evolution. We find
Study Population The study population included individuals aged 66 years or older at their time of cancer diagnosis; identified in claims data for services received during the last 6 months of life for active metastatic female breast, colorectal, lung, pancreas, or prostate cancer; and who died ...
摘要: BACKGROUND:Limited survival benefit and excess treatment because of prostate-specific antigen (PSA) screening in randomized trials suggests a need for more restricted selection of prostate biopsy candidates by discerning risk of histologically aggressive versus indolent cancer before biopsy....
Radical prostatectomy or watchful waiting in early prostate cancer. N Engl J Med. 2014;370(10):932-942.PubMedGoogle ScholarCrossref 2. Bolla M, Gonzalez D, Warde P, et al. Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin. N Engl ...