age-related bone lossBMUbone remodelingmenopause-related bone lossosteoblastThis chapter focuses on two major factors that compromise bone strength in women: the occurrence of menopause and the effects of advancing age. Bone remodeling is balanced during young adulthood with equal volumes of bone ...
With increasing age, serum calcium levels are increasingly maintained by resorption of calcium from bone rather than by absorption of calcium from the diet. Older persons also tend to eat diets which are low in calcium. They do not adapt to these diets by increasing the efficiency of calcium ...
There are few data on osteoporosis in men, but cross-sectional studies have shown that age-related bone loss in men is of lower magnitude than in women. To elucidate some controversies related partially to methodological aspects, we measured bone mineral density (BMD) by dual-energy X-ray abso...
von Wowern N, Stoltze K. The pattern of age related bone loss in man- dibles. Scand J Dent Res. 1980;88:134-146.Von Wowern N, Stoltze K. Pattern of age related bone loss in mandibles. Scand J Dent Res. 1980; 88:134-146. [PubMed: 6929561]...
During aging there is a gradual loss of bone mass due to dysregulation of signaling pathways. This may be due to a decline in physical activity with age and/or changes in hormones and other signaling molecules. In particular, hormones, such as PTH, have a circadian rhythm, which may be ...
TGFβ1 induces age-related bone loss by promoting degradation of TNF receptor-associated factor 3 (TRAF3), levels of which decrease in murine and human bone during aging. We report that a subset of neutrophils (TGFβ1+CCR5+) is the major source of TGFβ1
With age, inflammatory pathways are activated in bone tissue, and signals that promote bone formation are inhibited. This study contributes to the understanding of the molecular changes that occur in bone tissue during age-related bone loss and provides evidence that rapamycin is a drug of potential...
Although data from rodent systems are extremely useful in providing insights into possible mechanisms of age-related bone loss, concepts evolving from animal models need to ultimately be tested in humans.This review provides an update on mechanisms of age-related bone loss in humans based on the ...
Age-related bone loss is an important risk factor for fractures in the elderly; it results from an imbalance in bone remodeling mainly due to decreased bone formation. We have previously demonstrated that endogenous G protein–coupled receptor (GPCR)-driven Gi signaling in osteoblasts (Obs) restrai...
This work could one day give scientists another avenue for therapies the preventboneloss. "HDAC3 is a protein that's expressed in the cell nucleus and it's hard to do a lot about it," she said. "It would be difficult to change levels and activity. But we know we can modify glucocort...