Age-related bone loss involves a gradual and progressive decline, which is also seen in men. Markedly increased bone resorption leads to the initial fall in bone mineral density. With increasing age, there is also a significant reduction in bone formation. This is mostly due to a shift from ...
from nonself cells. Removal of sialic acid from TLR2 disabled cell recognition mediated by Siglec15 and inhibited consequential osteoclast fusion. Our finding of osteoclast recognition signaling is helpful in understanding the pathogenesis of different skeletal disorders and bone loss during aging. ...
Women gradually lose bone from the age of ~35 years, but around menopause, the rate of bone loss escalates due to increasing bone resorption and decreasing bone formation levels, rendering these individuals more prone to developing osteoporosis. The increased osteoclast activity has been linked to ...
Despite the reduction of sex hormones has been considered the first extrinsic cause of bone loss during aging, recent evidences revealed that bone failure begins before the decrease of sex steroids both in men and women [34]. In support of this, Almeida et al. [35] investigated that sex-...
Tooth Loss and Periodontitis in Older Individuals: Results From the Swedish National Study on Aging and Care BACKGROUND Due to the increasing number of older people, there is a need for studies focused on this population. The aims of the present study are to asses... S Renvert,RE Persson,...
This seems to be due to the fact that women with late menopause lose bone faster than those with early menopause. 展开 关键词: Aging Bone loss Bone mineral density Menopause Osteoporosis DOI: 10.1007/BF01623659 被引量: 39 年份: 1995
In addition, this study indicates that the prolonged exposure to SFA-HFD decreases bone formation and probably overall bone turnover, which on one hand may protect from bone loss due to aging or estrogen deficiency but on the other hand may decrease bone quality and may predispose to fractures...
In addition to classic inflammatory diseases such as RA, low-grade inflammation has been observed to play important roles in bone loss during aging and metabolic disorders.7,8,9Studies have shown that inhibiting the production of the proinflammatory secretome by senescent cells prevents age-associated...
Objective: To investigate the relationship between the level of sex hormones and the loss of bone mass in aging male rats.Methods: Thirty male Sprague-Dawley rats were equally divided into five age groups and sacrificed at 35,70,160,700 and 800 postnatal days(PD),followed by measurement of ...
Bone loss because of excessive GC signaling is ascribed to decreased osteoblastogenesis and reduced osteoblast function. Yet the effect of GCs on osteoblasts and bone mineralization are convoluted, exhibiting both negative and positive effects depending on the steroid concentration, cell differentiation sta...