Future genetic and functional studies of SAMP6 mice should therefore provide clues as to why the production of osteoblasts is reduced during aging in mice and humans.RobertL.JilkaandRobertJ.ShmooklerReisandStavrosSDOSInternational CongressJilka,Robert L,Shmookler R, et al.Age-related bone loss: ...
There are few data on osteoporosis in men, but cross-sectional studies have shown that age-related bone loss in men is of lower magnitude than in women. To elucidate some controversies related partially to methodological aspects, we measured bone mineral density (BMD) by dual-energy X-ray abso...
They do not adapt to these diets by increasing the efficiency of calcium absorption as young persons do. This altered regulation of calcium may contribute to the chronic depletion of calcium from bone in later years, a condition known as age-related osteoporosis....
Age-related losses in bone mineral density (BMD), muscle strength, balance, and gait have been linked to an increased risk of falls, fractures and disability, but few prospective studies have compared the timing, rate and pattern of changes in each of these measures in middle-aged and older...
In conclusion, there are important age-related changes in bone structure and density that affect whole-bone strength. Additional studies measuring whole-bone strength with aging are needed.doi:10.1007/8415_2012_137MatthewJ.SilvaKarlJ.JepsenSpringer Berlin Heidelberg...
Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) is an essential intermediate in the tricarboxylic acid (TCA) cycle. Studies have re...
Severity and pattern of bone mineral loss in endocrine causes of osteoporosis as compared to age-related bone mineral loss 来自 Semantic Scholar 喜欢 0 阅读量: 30 作者:D Dutta,P Dharmshaktu,A Aggarwal,K Gaurav,B Kulshreshtha 摘要: Data are scant on bone health in endocrinopathies from India...
TGFβ1 induces age-related bone loss by promoting degradation of TNF receptor-associated factor 3 (TRAF3), levels of which decrease in murine and human bone during aging. We report that a subset of neutrophils (TGFβ1+CCR5+) is the major source of TGFβ1
In conclusion, administration of AS abolished the age-related cellular senescent and enhances bone mass. Our studies strongly suggest that AS could be a potential therapeutic agent against age-related osteoporosis. Support or Funding Information This work is financially supported by National Institute of...
Plasticity and regulation of human bone marrow stromal cells:potential implication in the treatment of age-related bone loss. Histol Histopathol 19 : 151-157 Human bone marrow stroma contains pluripotent mesenchymal progenitor cells that can give rise to many mesenchymal lineages, including chondroblasts...