1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (PAF) is a potent activator of polymorphonuclear neutrophil (PMN) aggregation, exocytosis and chemotaxis. Specific desensitization of PMN to PAF suggests a receptor-mediated interaction. The binding of 1-[3H]-O-alkyl-2-acetyl-sn-glyceryl-3-...
Adult stem cells are defined as cells that have two central properties: self-renewal and differentiation. Many types of adult stem cells have the remarkable ability to undergo asymmetric mitotic divisions that produce two distinct daughter cells. Alternatively, they undergo symmetric divisions in a sto...
an activator of pyroptosis [114]. Intriguingly,AIM2is crucial in establishing inflammatory memory in mouse EpdSCs, enabling them to respond more efficiently to subsequent insults [115]. KCs also express high levels of NLRP10 in the EpdSC niche upon differentiation, driving inflammasome formation...
Adult stem cells are defined as cells that have two central properties: self-renewal and differentiation. Many types of adult stem cells have the remarkable ability to undergo asymmetric mitotic divisions that produce two distinct daughter cells. Alternatively, they undergo symmetric divisions in a sto...
The activity of several HATs has been studiedin vivoas well [94]. The Querkopf (Qkf) protein is a member of the MYST family of HATs and it is a transcriptional activator with histone acetylase activity. During embryonic development, Qkf is expressed throughout the brain but its expression ...
Whole-genome studies in psoriatic patients revealed SNPs (Single Nucleotide Polymorphisms) inAIM2, an activator of pyroptosis [114]. Intriguingly,AIM2is crucial in establishing inflammatory memory in mouse EpdSCs, enabling them to respond more efficiently to subsequent insults [115]. KCs also express...
Influence of nucleotide analogues 8-Br-cAMP, 8-Br-cGMP, and the PKC activator TPA on glial cell viability. (A) The highest concentration of 500 μM of the cGMP analogue 8-Br-cGMP had no significant effect on cell viability of olfactory ensheathing cells and Schwann cells. Schwann cell show...
In recent years, a large number of studies have contributed to our understanding of the immunomodulatory mechanisms used by multipotent mesenchymal stem cells (MSCs). Initially isolated from the bone marrow (BM), MSCs have been found in many tissues but
The identification of multipotential mesenchymal stem cells (MSCs) derived from adult human tissues, including bone marrow stroma and a number of connective tissues, has provided exciting prospects for cell-based tissue engineering and regeneration. This
For example, Nup133 binds to chromatin remodeling enzymes to turn on genes involved in neural induction [21] and Nup98 is a gene activator dynamically interacting with lineage-specific genes in ESCs induced towards neural differentiation. Other studies have enlightened the master role of Nup153 in...