The peripheral blood film is suspicious for acute promyelocytic leukemia (APL). Numerous abnormal promyelocytes are present with variable nuclear size and shape; and basophilic cytoplasm with granules that vary in number. Auer rods (often multiple) are visible in roughly 1/3 of the promyelocyte...
BCR/ABL fusion gene de- tected in acute promyelocytic leukemia: a case study of clinical and laboratory results [ J ]. Leuk Lymphoma, 2014,55 (2) :435-438.Xiaolin Sun,Yanli He,Cui Mao,Liwen Zhu,Xiaoming Qin,Shiang Huang. BCR/ABL fusion gene detected in acute promyelocytic leukemia: a ...
de Botton S, Chevret S, Coiteux V, Dombret H, Sanz M, San Miguel Jet al. Early onset of chemotherapy can reduce the incidence of ATRA syndrome in newly diagnosed acute promyelocytic leukemia (APL) with low white blood cell counts: results from APL 93 trial.Leukemia2003;17: 339–342. ...
Acute Promyelocytic Leukemia: A Paradigm for Differentiation Therapy Acute promyelocytic leukemia(APL) is characterized by the t(15;17) chromosomal translocation leading to the formation of the PML-RARalpha oncoprotein. This... D Grimwade,AR Mistry,E Solomon,... - 《Cancer Treat Res》 被引量: ...
Twenty-two patients with acute promyelocytic leukemia were treated with all-trans retinoic acid (RA, 45 mg/m2 per day) for 90 days. Of the 22, four patients were previously untreated, two were resistant after conventional chemotherapy, and 16 were in first (n = 11), second (n = 4), ...
Acute promyelocytic leukemia (APL) is distinguished from other acute myeloid leukemias (AMLs) by cytogenetic, clinical, as well as biological characteristics. The hallmark of APL is the t(15;17), which leads to the expression of the PML/RARα fusion protein. PML/RARα is the central leukemia...
Acute promyelocytic leukemia (APL) is a unique subtype of the acute leukemias. It has distinct cytogenetics, clinical features, and biologic characteristics.
Bernard J, Weil M, Boiron M, Jacquillat C, Flandrin G, Germon MF Acute promyelocytic leukemia: results of treatment by daunorubicin Blood, 41 (1973), pp. 489-496 View PDFView articleCrossrefView in ScopusGoogle Scholar Cited by (0)Supported in part by the Leukemia Research Fund, Inc. ...
Additional eligibility criteria include having an ECOG performance status of 0 to 2, adequate laboratory results, and no receipt of any investigational therapies within 4 weeks of entry. Those with acute promyelocytic leukemia, prior mediastinal radiotherapy, central nervous system involvement, or ...
Acute promyelocytic leukemia (APL) falls into the latter category. It is composed of malignant promyelocytes, which often have a distinctive appearance. But the really characteristic finding in APL is the faggot cell, so named because it contains a ton of Auer rods all piled up on each ...