Leukemia, Promyelocytic, AcuteRecurrenceIdarubicinMitoxantroneCytarabineNeoplasm ProteinsOncogene Proteins, FusionSalvage TherapySurvival AnalysisDaunorubicin induces complete remissions in about 50% of patients with acute promyelocytic leukemia. The median duration of these remission is 26 mo. Failures are mainly ...
Acute promyelocytic leukemia (APL) is characterised by balanced translocation between the longarms of chromoso)ne 15 and 17 resulting in formation of fusion protein PMLlRARa. Due to thisabnormal fusion protein, myeloid cell differentiation is arrested at the promyelocyte level. Thismolecular defect ...
Acute promyelocytic leukemia (APL) is designated M3 in the French-American-British (FAB) classification. Because of its unique clinical features and unique response to certain differentiation-inducing agents, and because of our advanced understanding of
Fifty-seven patients in initial phase of acute promyelocytic leukemia (APL) were treated in the same department with heparin infusion, platelet transfusions, and two related induction regimens both including cytosine arabinoside and daunorubicin. Clinical and biological findings at presentation were studied...
Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all-trans retinoic acid (ATRA). With considerable advances in thera
et al. All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc. Natl Acad. Sci. USA 101, 5328–5335 (2004). Article CAS PubMed PubMed Central Google Scholar Estey, E. et al. Use of all-trans retinoic ...
Define acute promyelocytic leukemia. acute promyelocytic leukemia synonyms, acute promyelocytic leukemia pronunciation, acute promyelocytic leukemia translation, English dictionary definition of acute promyelocytic leukemia. n. Any of various acute or ch
Effectiveness and pharmacokinetics of low-dose all-trans retinoic acid (25 mg/m2) in acute promyelocytic leukemia. It has been shown that all-trans retinoic acid (ATRA) at doses of 45 to 100 mg/m2/d induces complete remission (CR) of acute promyelocytic leukemia (APL) b... S Castaigne...
Related to acute myelomonocytic leukemia:Acute monocytic leukemia,acute promyelocytic leukemia leu·ke·mi·a (lo͞o-kē′mē-ə) n. Any of various acute or chronic neoplastic diseases of the bone marrow in which unrestrained proliferation of white blood cells occurs, usually accompanied by anemi...
Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity Arsenic trioxide, as a single agent, has proven efficacy in inducing molecular remission in patients with acute promyelocytic leukemia (APL). There is limi... V Math...