Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML), with the first description as a distinct entity in 1957.1The disease is identified by distinctive morphology and is distinguished by a balanced reciprocal translocation between chromosomes 15 and 17. Historically, ...
Acute promyelocytic leukemia (APL) is characterised by balanced translocation between the longarms of chromoso)ne 15 and 17 resulting in formation of fusion protein PMLlRARa. Due to thisabnormal fusion protein, myeloid cell differentiation is arrested at the promyelocyte level. Thismolecular defect ...
leukemia美— 血癌 leukemia美名— 疾患名 使用DeepL翻译器,即刻翻译文本和文档 随打随译 世界领先的质量 拖放文件 立刻翻译 ▾ 外部资源(未审查的) [...] Substances are administered for the treatmentofacute promyelocytic leukemiaandcryopyrin-associated ...
Survival of acute promyelocytic leukemia at MD Anderson (1970–2020). Full size image Core-binding factor acute myeloid leukemia The CBF AMLs include the subsets with chromosomal abnormalities involving inversion 16/t (16; 16) or t (8; 21). These constitute 10–15% of adult AML cases. The...
Mead,Adam - 《Current Medical Literature Leukemia & Lymphoma》 被引量: 633发表: 2013年 PML, a growth suppressor disrupted in acute promyelocytic leukemia. The nonrandom chromosomal translocation t(15;17)(q22;q21) in acute promyelocytic leukemia (APL) juxtaposes the genes for retinoic acid receptor...
What is the survival rate for AML? This is tough to answer because there are many different types of AML, and each type has differences in treatment options and survival rates. In general: People younger than 65 usually fare better than older people. ...
As mentioned earlier (see Chapter 20), patients with inv(16) have a favorable prognosis, and those with translocation of 11q23 fall into the category of leukemias with intermediate survival rate. Some studies show a correlation between the expression of CD56 by the leukemic cells and severe ...
Define acute promyelocytic leukemia. acute promyelocytic leukemia synonyms, acute promyelocytic leukemia pronunciation, acute promyelocytic leukemia translation, English dictionary definition of acute promyelocytic leukemia. n. Any of various acute or ch
Nonetheless, persistence or acquisition of an abnormal karyotype has long been associated with higher relapse rate and shortened survival [19,20,21,22]. Detection of persistent leukemia-associated karyotypes in CR is thus strongly suggestive that residual leukemia cells are present in a background ...
Our knowledge about acute promyelocytic leukemia (APL) patients is mainly based on data from clinical trials, whereas population-based information is scarce. We studied APL patients diagnosed between 1997 and 2006 in the population-based Swedish Adult Acute Leukemia Registry. Of a total of 3897 acut...