Elderly (especially over age 75) patients have special treatment concerns. They may be less able to tolerate the septicemia (blood poisoning) associated with loss of granulocytes and they often have higher rates of myelodysplastic (’pre-leukemia’) syndrome (MDS). High dose chemo is unlikely to...
The Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N. Engl. J. Med. 368, 2059–2074 (2013). Falini, B. et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N. Engl. J. Med. 352, 254–...
Acute myeloid leukemia: epidemiology and etiology. Cancer 107, 2099–2107 (2006). Article PubMed Google Scholar Corces-Zimmerman, M. R., Hong, W. J., Weissman, I. L., Medeiros, B. C. & Majeti, R. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and ...
Progress in the understanding of the biology and therapy of acute myeloid leukemia (AML) is occurring rapidly. Since 2017, nine agents have been approved for various indications in AML. These included several targeted therapies like venetoclax, FLT3 inhi
Nucleophosmin status may influence the therapeutic decision in de novo acute myeloid leukemia with normal karyotype. Sang Research Fund, U.K Approximately 45% of patients with de novo acute myeloid leukemia (AML) have a normal karyotype (nk-AML). The complete remission (CR) rates for this group...
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with an incidence that increases with age, and a generally poor prognosis. The disease is clinically and genetically heterogeneous, and recent advances have improved our un
Acute myeloid leukemia (AML) is a heterogeneous group of disorders defined by the proliferation of immature hematopoietic elements. The prototypical disease is characterized by an expansion of immature myeloid cells (myeloblasts) to comprise 20% or greater of the bone marrow or peripheral blood hema...
Immunophenotypic evidence of leukemia after induction therapy predicts relapse: results from a prospective Children’s Cancer Group study of 252 patients with acute myeloid leukemia. Blood. 2003;101(9):3398-3406. doi:10.1182/blood-2002-10-3064 PubMedGoogle Scholar 40. Coustan-Smith E...
Chemotherapy-resistant cancer recurrence is a major cause of mortality. In acute myeloid leukemia (AML), chemorefractory relapses result from the complex interplay between altered genetic, epigenetic and transcriptional states in leukemic cells. Here, we
Acute Myeloid Leukemia: An Update Chapter © 2019 References Cancer Research UK. Acute myeloid leukaemia (AML) incidence statistics. Cancer Research UK[online], (accessed Jan 2015). Derolf, A. R. et al. Improved patient survival for acute myeloid leukemia: a population-based study of 9729 ...