activation-induced cytidine deaminase expression 是活化诱导胞嘧啶核苷脱氨酶的表达的意思
A major breakthrough came in 2000 with the discovery that activation-induced deaminase (AID) is absolutely required for hypermutation. This was followed in 2002 by evidence that AID directly edits the DNA that encodes an antibody in an activated B cell. Much has since been learnt about the ...
网络活化诱导的细胞死亡;激活诱导的细胞死亡 网络释义
Activation-induced cytidine deaminase (AID) is critically involved in class switch recombination and somatic hypermutation of Ig loci resulting in diversification of antibodies repertoire and production of high-affinity antibodies and as such represents a physiological tool to introduce DNA alterations. These...
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(redirected fromactivation-induced cell death) Dictionary Thesaurus Legal Acronyms Encyclopedia Death Definition Death is defined as the cessation of all vital functions of the body including the heartbeat, brain activity (including the brain stem), and breathing. ...
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Yet both depend on activation-induced deaminase (AID), the function of which in the two reactions has been an enigma. Here we report that B cell stimulation which induces CSR but not SHM, leads to AID-dependent accumulation of SHM-like point mutations in the switch mu region, uncoupled ...
Siva-1 negatively regulates NF-κB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD). Ligation of TCRs on stimulated T cells leads to activation-induced cell death (AICD) resulting in the downregulation of immune responses, a process essenti... Gudi,R.,Barkinge...
Conversely, approaches to render NKT cells hyporesponsive may constitute new therapeutic strategies for diseases, where aberrant NKT cell activation is causally involved. 展开 关键词: lymphocytes natural killer T cells tolerance liver immunology anergy animal models ...