近日,海军军医大学史建刚研究团队在Advanced Science发表了题为Glycolysis-Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration的研究成果,揭示髓核细胞糖酵解异常激活,过量...
OBJECTIVE:To summarize the structural function and regulatory mechanism of ACSL4 and its potential molecular mechanism mediating ferroptosis, and to elaborate the application of ACSL4 driving ferroptosis in atherosclerosis, ischemic stroke and myocardial infarction, in order to provide a new therapeutic str...
2024年9月25日,浙江大学王福俤、傅国胜、闵军霞共同通讯在Signal Transduction and Targeted Therapy在线发表题为“Characterization of ferroptosis-triggered pyroptotic signaling in heart failure”的研究论文,该研究结果表明,ACSL4在压力过载...
因此,凝血酶-ACSL4轴可能是改善缺血性脑卒中铁性神经元损伤的关键治疗靶点。本文于2022年2月发表于Signal Transduction and Targeted Therapy (IF= 39.3)。 技术路线 主要研究结果 (1) 急性脑I/R后凝血酶上调 由铁死亡引起的细胞死亡是由于有毒的脂质氢过氧化物积累超过细胞解毒的能力。含有phosphatidyl ethanolamine(...
近期,来自密歇根大学医学院邹伟平团队在Cancer Cell 杂志发表题为“CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4”的研究型文章,该文章发现T细胞衍生的干扰素 (IFN)γ与花生四烯酸(AA)结合可诱导肿瘤铁死亡[3]。 研究人员探索了IFNγ协同花生四烯酸诱导肿瘤细胞铁死亡的机制。酰...
Ferroptosis, which is driven by iron-dependent lipid peroxidation, plays an essential role in liver ischemia-reperfusion injury (IRI) during liver transplantation (LT).Gp78, an E3 ligase, has been implicated in lipid metabolism and inflammation. However, its role in liver IRI and ferroptosis remai...
本研究结果为AKI和铁死亡相关疾病新治疗方法的开发提供了参考。 参考文献: Wang Y, Zhang M, Bi R, et al. ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury[J]. Redox Biology, 2022: 102262.
近期,来自密歇根大学医学院邹伟平团队在Cancer Cell 杂志发表题为“CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4”的研究型文章,该文章发现T细胞衍生的干扰素 (IFN)γ与花生四烯酸(AA)结合可诱导肿瘤铁死亡[3]。 研究人员探索了IFNγ协同花生四烯酸诱导肿瘤细胞铁死亡的机制。酰...
(FIN)to trigger tumor ferroptosis and promote anti-tumor immunity in an acyl-coenzyme A synthetase long-chain family member 4(ACSL4)-dependent manner.Ferroptosis refers to a form of regulated cell death triggered by excessive iron-dependent peroxidation of PUFA-containing phospholipids(PUFA-PLs)in ...
ferroptosis partly by suppressing the expression of SLC7A11 (Fig.1); however, IFNγ treatment alone fails to induce obvious ferroptosis in tumor cells.4,5Reasoning that IFNγ likely needs to cooperate with other factors to induce ferroptosis and considering the intimate link between ferroptosis and...