Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that occur in lipid metabolism during ferroptosis and have provided intriguing insights into the interplay between ferroptosis and ...
11Therefore, the regulation of lipid metabolism and ferroptosis offers several potential strategies for treating cancer. In this review, we will discuss the interaction between ferroptosis and lipid metabolism in cancer.
Lipid Metabolism and Ferroptosis While increasing incorporation of PUFAs into phospholipids via enzymes like LPCAT3 is essential to maintain membrane fluidity, this carries a risk as high amounts of PUFA-containing membrane lipids sensitize cancer cells to ferroptosis, a specific form of cell death....
Lipid metabolism refers to the process of digestion, absorption, synthesis, and decomposition of fats in living organisms by various enzymes. From:Biomedicine & Pharmacotherapy,2023 Also in subject areas: Agricultural and Biological Sciences Earth and Planetary Sciences ...
article reviews the potential role of ferroptosis in AD, the involvement of ferroptosis in the pathological progression of AD through the mechanisms of iron metabolism, lipid metabolism, and redox homeostasis, as well as a range of potential therapies targeting ferroptosis for AD. Intervention ...
Nevertheless, the role of ZDHHC6 in lipid metabolism is largely unknown. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in controlling lipid metabolism and energy balance, which are important biological processes involved in the advancement of colorectal cancer (CRC) [...
In cell-assisted lipotransfer technology, adipose-derived stem cells (ASCs) can influence the inflammatory response of grafts through the immunoregulation in macrophages, and the lipid metabolism in macrophages plays an important role in this process. Therefore, we hypothesized ASCs could improve the ...
thetase long chain family member 4 (ACSL4), a lipid metabolism enzyme required for lipid peroxidation 9–11 .The degree of lipid peroxidation-product accumulation, which is regulated by the generation and scavenging of lipid peroxide, is recognized as a determinant of ferroptosis occurrence 12,13...
Intrinsic temperature increase drives lipid metabolism towards ferroptosis evasion and chemotherapy resistance in pancreatic cancer The development of cancer is typically accompanied by changes in the tumor microenvironment that support tumor growth and affect therapy response. Here, the authors show that in...
ACSL1-induced ferroptosis and platinum resistance in ovarian cancer by increasing FSP1 N-myristylation and stability ArticleOpen access Introduction Reprogrammed fatty acid metabolism mainly characterized by increased de novo lipgenesis has been increasingly established as a hallmark of cancer. Elevated lip...