Stockwell, Ferroptosis: death by lipid peroxidation, Trends Cell Biol. 26 (2016) 165-176, http://dx.doi.org/10.1016/j.tcb.2015.10.014.Yang WS, Stockwell BR (2016) Ferroptosis: death by lipid perox- idation. Trends Cell Biol 26(3):165-176. https://doi.org/10.1016/j. tcb.2015.10....
Ferroptosis represents a form of programmed cell death that is propelled by iron-dependent lipid peroxidation, thereby being distinguished by the prominent features of iron accumulation and lipid peroxidation. Ferroptosis has been implicated in numerous physiological and pathological phenomena, with mounting ...
MT-1G knockdown contributed to sorafenib-induced ferroptosis by increasing lipid peroxidation and GSH depletion. CDGSH iron sulfur domain 1 (CISD1) and ACSL4 inhibition promote erastin-induced ferroptosis in HCC. Low-density lipoprotein (LDL)–docosahexaenoic acid (DHA) nanoparticles cause cell death ...
Ferroptosis is a non-apoptotic form of regulated cell death that is triggered by the discoordination of regulatory redox mechanisms culminating in massive peroxidation of polyunsaturated phospholipids. Ferroptosis inducers have shown considerable effecti
Cancer metabolism mainly includes carbohydrate, amino acid and lipid metabolism, each of which can be reprogrammed. These processes interact with each other to adapt to the complicated microenvironment. Ferroptosis is a regulated cell death induced by iron-dependent lipid peroxidation, which is morphologi...
We previously demonstrated that iron-containing nanomaterials (e.g., Fe3O4 and Fe3S4) can directly kill bacteria by releasing ferrous iron (not ferric iron) to induce lipid peroxidation in bacteria . These hallmarks of ferrous iron dependence and lipid peroxidation in bacteria are the same as ...
Ferroptosis: Death by Lipid Peroxidation Ferroptosis is a regulated, nonapoptotic form of cell death distinct from other cell death modalities. Loss of GPX4 activity and subsequent accumulation of... SY Wan,BR Stockwell - 《Trends in Cell Biology》 被引量: 194发表: 2015年 Disulfidptosis: a no...
(GPX4). When intracellular lipid ROS levels exceed the antioxidant activity of GPX4, redox homeostasis is broken, which eventually leads to cell death [7]. However, sex hormones can reduce iron decline and ultimately inhibit iron death by modulating MBOAT1 and MBOAT2 expression to reshape ...
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation and lipid peroxidation. It is closely related to multiple biological processes, including iron metabolism, polyunsaturated fatty acid metabolism, and the biosynthes
Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation. Inflammation is one common and effective physiological event that protects against various stimuli to maintain tissue homeostasis. However, the dysregulation of inflammatory responses can cause imbalance of the immun...