Ferroptosis is a distinct form of necrotic cell death caused by overwhelming lipid peroxidation, and emerging evidence indicates a major contribution to organ damage in multiple pathologies. However, ferroptosis has not yet been visualized in vivo due to a lack of specific probes, which has severely...
Ferroptosis is an iron-dependent, oxidative, non-apoptotic form of cell death initially described in mammalian cells. We recently reported that a ferroptosis-like cell death process can be triggered by heat shock in Arabidopsis thaliana . Thus, ferroptosis may be a form of cell death conserved be...
We report a strategy to boost Fenton reaction triggered by an exogenous circularly polarized magnetic field (MF) to enhance ferroptosis-like cell-death mediated immune response, as well as endow a responsive MRI capability by using a hybrid core-shell ve
Ferrous polysulfide Nano-decoction Ferroptosis- like death Intracellular bacteria Anti- infection therapy 1 Introduction Bacterial infection is a major global threat to public health and is continuing to worsen due to the rapid evolution of pathogenic bacteria, which can generate antibiotic resistance, fo...
During in vitro and in vivo experiments, we observed that PPR NPs could enter LPS-treated renal tubular cells and IRI kidneys of mice, eliminate ROS, repair mitochondria, suppress ferroptosis, reduce cell death, and protect kidneys from IRI damage. Overall, our study suggests that PPR NPs ...
Eosinophils are critical in allergic disorders, and promoting eosinophil death effectively attenuates allergic airway inflammation. Ferroptosis is a recently described novel form of cell death; however, little is known about ferroptosis in eosinophils and related diseases. This study aimed to investigate ...
A significant tumor suppression is achieved by Fenton reaction-mediated ferroptosis-like cell-death. The oxidative stress induced by the Fenton reaction leads to the exposure of calreticulin on tumor cells, which leads to dendritic cells maturation and the infiltration of cytotoxic T lymphocytes in ...
Development of phenol-tolerant E. coli strains via adaptive evolution provides insight into the molecular mechanism of phenol toxicity and highlights the potential of phloroglucinol-induced ferroptosis-like cell death in cancer biology.Communications Biology...
Overall, these data point to a marked neurotoxic potential of Co-based but not WC NPs and show that neuronal cell death may occur through a ferroptosis-like mechanism.doi:10.1096/fj.201902191RRJohn Wiley & Sons, LtdThe FASEB Journal
Ferroptosis is mechanistically and morphologically different from other forms of cell death, such as apoptosis; it therefore has great potential for cancer therapy. Tumor-cell chemoresistance, caused by adaptive tolerance to apoptosis, can be treated by inducing ferroptosis11. Hence, it would be ...