The hydrolysis of peptide-amides in the solid state at 4掳 due to the presence of residual strong acid was investigated. It was found that even small molar excesses of these acids cause substantial deamidation in one day. The degree of amide hydrolysis depends not only upon the pKa and the...
Synthesis of poly(succinimide-amide) by acid-catalyzed polycondensation of L-aspartic acid and aromatic aminocarboxylic acid 喜欢 0 阅读量: 26 作者:T Nakato,M Tomida,A Kusuno,ST Kakuchi 摘要: The polycondensations of L-aspartic acid (1) with aromatic aminocarboxylic acid, 4-aminobenzoic acid ...
The conjugate acid of the imidic acid loses a proton, and the resulting imidic acid tautomerizes to give an amide. The amide continues to react by the mechanism of acid-catalyzed amide hydrolysis we discussed above. Sign in to download full-size image In the base-catalyzed hydration of a...
catalysis is growing rapidly a number of crucial factors remain to be investigated[151-164]. Kirbyet al.have researched the mechanism of the acid catalyzed hydrolysis of N-alkylmaleamic acids7-15to their correspondingmaleamic acidsand amines (Fig.10). The study found that the reaction is ...
The base-catalyzed, kOH-, pathway was mainly affected by the steric bulk of the nitrogen substituents in the amide moiety, the reactivity being reduced with larger N-substituents. Hydrolysis in human plasma appeared to be mediated by enzymic processes and is dependent upon the steric bulk in ...
Synthesis of (+)-coronafacic acid An enantioselective synthesis of (+)-coronafacic acid has been achieved. Rhodium-catalyzed cyclization of an alpha-diazoester provided the intermediate cyc... DF Taber,RB Sheth,W Tian - 《Journal of Organic Chemistry》 被引量: 28发表: 2009年 A Concise Synt...
PreparationSuccinic acid can also be manufactured by catalytic hydrogenation of malic or fumaric acids. It has also been produced commercially by aqueous acid or alkalihydrolysis of succinonitrile derived from ethylene bromide and potassium cyanide (Gergel and Revelise, 1952; Gardner, 1972). ...
These protons are present in the maleic moeity of CLEFMA structure (Fig. 1), indicating the possibility of an acid-catalyzed hydrolysis of the amide bond. We analyzed the 4.5 min-peak by mass spectroscopy (Fig. S3). The [M+H]+ peak of 344 Da in the mass spectroscopy data confirmed ...
Acid-catalyzed hydrolysis should be avoided because of the likelihood of formation of anhydroretinol from retinol. If the sample does not contain sufficient amounts of natural antioxidants, it is recommended that an antioxidant be added before saponification. View chapterExplore book Introduction to ...
Simple benzo ester and amide also afford the desired products (3–33, 3–34). The dienedioic acid 1–2 and bromobenzene can also provide compound 3–6 via first decarboxylative coupling, followed by hydrolysis (3–38). From compound 3–38, various transformations can take place based on ...