The rates of the acid-catalyzed decarboxylation and amide hydrolysis of α-ketoglutaramic acid, the keto analog of glutamine, were investigated and the products of the reactions were characterized. In strong acid at 100°C, amide hydrolysis and decarboxylation occur with about equal facility, ...
The conjugate acid of the imidic acid loses a proton, and the resulting imidic acid tautomerizes to give an amide. The amide continues to react by the mechanism of acid-catalyzed amide hydrolysis we discussed above. Sign in to download full-size image In the base-catalyzed hydration of a...
Patterson, et al., “Inhibition of Oleamide Hydrolase Catalyzed Hydrolysis of the Endogenous Sleep-Inducing Lipid cis-9- Octadecenamide”, J. Am. Chem. Soc. 118: 5938-5945 (1996). Cravatt, et al., “Molecular Characterization of an Enzyme that Degrades Neuromodulatory Fatty-Acid Amides”, Na...
productivityoftheconversioncatalyzedbythe fungalcellswasextremelylow(lessthan2mmol l −1 within7days). Here,wedescribethehydrolysisoflysergamide byRhodococcusequiA4.Thisenzymaticreaction proceedswithahighC-8stereoselectivity(Fig.1) andprovidesaconvenientroutetolysergicacid ...
Simple benzo ester and amide also afford the desired products (3–33, 3–34). The dienedioic acid 1–2 and bromobenzene can also provide compound 3–6 via first decarboxylative coupling, followed by hydrolysis (3–38). From compound 3–38, various transformations can take place based on ...
Michaelis–Menten kinetics for the hydrolysis of the substrates (2.5 μM) in the presence of CuL1 (5.0–25 μM) in a 10% MeCN solution in HEPES buffer (pH 7.2, 50 mM) at 298 ± 0.1 K. kcat (10−5 s−1) Km (μM) kcat/Km (M−1 s−1) kuncat (10...
Chapter 4 offers an extensive description of the citric acid chemistry. It includes presentation of total syntheses of citric acid, preparations of labeled citric acid, typical reactions – neutralization, degradation, oxidation, esterification, formatio
Acid-catalyzed hydrolysis should be avoided because of the likelihood of formation of anhydroretinol from retinol. If the sample does not contain sufficient amounts of natural antioxidants, it is recommended that an antioxidant be added before saponification. View chapter Book 2019, Laboratory ...
Acid-Catalyzed Hydrolysis of Semi-Aromatic Polyamide NF Membrane and Its Application to Water Softening and Antibiotics Enrichment. Chem. Eng. J. 2018, 332, 419–430. [CrossRef] 126. Ren, Y.; Zhu, J.; Feng, S.; Chen, X.; Luo, J.; Wan, Y. Tuning Pore Size and Surface Charge of...
In vitro hydrolysis of amide IAA conjugates was shown with applied conjugates,39 and a specific conjugate hydrolase was induced in Chinese cabbage with Plasmodiophora brassicae infection.40 Auxin conjugates have also been used as ‘slow-release’ forms of IAA in plant tissue cultures.41 A genetic ...