28,29 We tested a clinical-grade AAV9-GFP, a vector comparable with AVXS-101, but with a GFP transgene instead of SMN, at the same weight-based dose. We chose to do an open injection technique to avoid any technical variability from ultrasound-guided injections (which are performed ...
Colle, M-AGene TherapyK. Bey, C. Ciron, L. Dubreil, J. Deniaud, M. Ledevin, J. Cristini, V. Blouin, P. Aubourg, M. A. Colle, Efficient CNS targeting in adult mice by intrathecal infusion of single- stranded AAV9-GFP for gene therapy ...
Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery Danielle Weber-Adrian, Rikke Hahn Kofoed, Joseph Silburt, Zeinab Noroozian, Kairavi Shah, Alison Burgess, Shawn...
C3013-250μl AAV-mCherry-GFP-LC3B (AAV9, 10^13vp/ml) 250μl 6195.00元 AAV-mCherry-GFP-LC3B (AAV9),即AAV9 serotype adeno-associated virus (AAV) expressing mCherry-GFP-LC3B fusion protein,是一种可表达mCherry-GFP-LC3B融合蛋白的腺相关病毒,用于注射小鼠等动物后进行细胞自噬(autophagy)检测。
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2013. Systemic delivery of shRNA by AAV9 provides highly efficient knockdown of ubiquitously expressed GFP in mouse heart, but not liver. PLoS ONE 8, e75894.Piras BA, O'Connor DM, French BA. Systemic delivery of shRNA by AAV9 provides highly efficient knockdown of ubiquitously expressed GFP...
RaBGGTBAAV9自噬肌萎缩侧索硬化(Amyotrophic lateral sclerosis,ALS)是目前较罕见的一种神经退行性疾病,可选择性侵犯大脑皮质锥体细胞,锥体束,脑干运动核团及脊髓灰质前角神经元,造成运动神经元的损伤及变性.流行病学统计数据显示,ALS年发病率约为0.4-2.6/10万,以散发病例为主(s ALS),但仍有约5%-10%的患者为家族...
We evaluated the quantity of viral DNA from the serotypes AAV9, AAV6, and a mosaic AAV1&2, expressing green fluorescent protein (GFP) under the neuron-specific synapsin promoter (syn). AAVs were administered intravenously during MRIgFUS targeting to the striatum and hippocampus in mice. The...
Intrathecal sc-AAV9-CB-GFP: Systemic Distribution Predominates Following Single-Dose Administration in Cynomolgus Macaquesdoi:10.1101/2021.11.28.470258Emily K MeseckGhiabe GuibingaStephen WangCameron McElroyEloise HudryKeith MansfieldCold Spring Harbor Laboratory...
Robust XII motoneuron GFP expression was observed in the caudal XII nucleus after either single or dual AAV9 injection; initial observations suggest no differences in XII motoneuron transduction between the two delivery methods. With both approaches, GFP expression was primarily restricted to XII moto...