1. An adeno-associated virus (AAV) comprising an AAV capsid comprising an AAVrh 10 vp1, comprising amino acids 1 to 738 of SEQ ID NO:81 or a sequence which is at least 95% identical therewith, a minigene having AAV inverted terminal repeats (ITRs), and a heterologous gene operably ...
PRAAV2XP AAV2 Xpress ELISA 96 tests ELISA 2-8°C PRAAV3R AAV3 Titration ELISA 2.0R 96 tests ELISA 2-8°C PRAAV5 AAV5 Titration ELISA 96 tests ELISA 2-8°C PRAAV5XP AAV5 Xpress ELISA 96 tests ELISA 2-8°C PRAAV6 AAV6 Titration ELISA 96 tests ELISA 2-8°C PRAAV6XP AAV6...
Intravenously administered AAV is broadly distributed, and evidence that AAV vectors packaged using capsid serotypes 9 and rh10 can cross the blood-brain barrier [[37], [38], [39], [40], [41], [42]] additionally raises the prospect for the potential effectiveness of intravenous delivery as...
An adeno-associated virus (AAV) comprising an AAV capsid comprising a vp1 AAVrh10, quecomprende amino acids 1 to 738 of SEQ ID NO. 81 or a sequence that is at least 95% identical thereto, a minigene that has inverted terminal repeats (ITRs) of AAV, and enlazadooperativamente ...
Our analysis revealed a total of 52 post‐translational modifications in AAV2‐AAVrh10 capsids, including ubiquitination (17%), glycosylation (36%), phosphorylation (21%), SUMOylation (13%) and acetylation (11%). While AAV1 had no detectable post‐translational modification, at least four ...
Thus, AAV-rh10 carries promising potential as a gene therapy vector, particularly if both the neuronal and glial cell populations in damaged spinal cord are targeted.doi:10.1038/gt.2014.74Petrosyan, H AAlessi, VSingh, VHunanyan, A SLevine, J M...
RH10 provides superior transgene expres- sion in mice when compared with natural AAV serotypes for neonatal gene therapy. J Gene Med 2010;12:766-78.Hu C, Busuttil RW, Lipshutz GS. RH10 provides superior transgene expression in mice when compared with natural AAV serotypes for neonatal gene...
Data on such post‐translational modifications in the capsid of recombinant adeno‐associated virus serotypes (AAV 1‐rh10) is limited. We have employed liquid chromatography and mass spectrometry analysis to characterize post‐translational modifications in AAV 1‐rh10 capsid protein. Our analysis ...
AAV\n1‐rh10 capsid protein. Our analysis revealed a total of 52 post‐translational modifications in\nAAV\n2‐\nAAV\nrh10 capsids, including ubiquitination (17%), glycosylation (36%), phosphorylation (21%),\nSUMO\nylation (13%) and acetylation (11%). While\nAAV...
A method for dctecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided. The invention further provides AAV sequences identified by this method, and vectors constructed using these sequences.Gao GuangpingWilson James M.Alvira Mauricio...