研究人员利用腺相关病毒(AAV-miR-15b-5p sponge)载体感染CAC和APCMin/+小鼠结肠组织,抑制miR-15b-5p的表达。作者观察发现在CAC和APCMin/+结肠癌小鼠模型中,miR-15b-5p表达的阻断明显促进了肿瘤的发生,提高了PD-L1表达,同时显著减少了CD8+细胞数量,说明miR-15b-5p通过靶向PD-L1抑制肿瘤的发生。 图1. miR-15b-...
The administration of AAV:miR-206 or AAV:miR-206-sponge vectors does not affect post-natal skeletal muscle massCatherine, E. WinbanksClaudia, BeyerAdam, HaggHongwei, QianPatricio, V. SepulvedaPaul, Gregorevic
Design and validation of AAV:miRNA-206 and AAV:miR206-sponge vectors.Catherine, E. WinbanksClaudia, BeyerAdam, HaggHongwei, QianPatricio, V. SepulvedaPaul, Gregorevic