miR-15a-5p MicroRNAs (miRNAs) are small non-coding RNA molecules, approximately 22 nucleotides in length that regulate gene translation through silencing or degradation of target mRNAs. They are involved in multiple biological processes, including differentiation and proliferation, metabolism, hemostasis, ...
研究发现,HDAC1 在海人酸诱导的 SE 中高表达。敲低 HDAC1 可缓解 SE 症状,抑制裂解的 Caspase-1、GSDMD-N、IL-1β 和 IL-18,抑制海马神经元焦亡。HDAC1 与 miR-15a-5p 启动子结合,降低 H3K9ac,从而抑制 miR-15a-5p 表达。miR-15a-5p 与 Caspase-1 结合并抑制其表达。抑制 miR-15a-5p 或过表达 Caspas...
过表达miR-15a-5p抑制食管癌细胞中总PD-L1及膜PD-L1表达(P<0.05).在食管癌细胞中过表达miR-15a-5p可促进共培养体系中CD8+T细胞的激活(即:共培养体系中INF-γ阳性CD8+T细胞比例以及共培养体系中上清液中INF-γ和IL-2含量增加).结论miR-15a-5p可通过靶向PD-L1增强食管癌细胞的肿瘤免疫反应,且miR-15a-5p/PD...
mir-15a-5p 激活剂 (共29件相关产品信息) 更新时间:2022年02月16日 品牌 抚生 CRK Pharma 润裕 仑昌硕 赤乐川 库巴鲁 子科生物ZIKER 仁捷生物 mlBio 博研生物 westang 心语 索莱宝 雅吉/GTX 一研 gelatins/江蓝纯 睿信生物 德盛稀土 科顺生物 臻科生物 金恩洋 联合益农 远成 雄冠 箘健 菌健 舒话...
miR-15a-5p alone yieldedan AUC value of 0.813 to distinguish EC patients with stage I from healthy subjects. The integration of miR-15a-5pand serum tumor markers (CEA and CA125) achieved a higher AUC value of 0.899. There was also a closeconnection between miR-15a-5p and clinical manifest...
货号:cgr-miR-15a-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:cgr-miR-15a-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
In our in vivo study, LNA-15a treatment significantly suppressed the tumor growth, and prolonged the survival of mice compared with the control group. However, our results indicated that the native form of oligo-single-stranded DNA mimic of hsa-miR-15a-5p (OMM-15a) without any modification ...
基因方法验证miR-15a-5p和miR-16-5p与CCND1基因之间的作用关系.结果:通过基因测序表明,本实验成功构建了CCND1a/Ma和CCND1b/Mb荧光素酶报告基因表达载体.将上述载体应用于荧光素酶报告基因实验,结果发现CCND1b组的荧光素酶表达强度显著降低,差异有统计学意义(P〈0.05).结论:miR-15a-5p和miR-16-5p与CCND1基因...
β1的关键调控因子,分为受体调节型(R-Smads),抑制型(I-Smads)和协同调节型(Co-Smads).Smad7属于I-Smads,是TGF-β1信号通路的抑制剂.miRNA是保守的18-25个核苷酸的非编码RNA,通过与mRNA3′非翻译区(3′UTR)碱基配对从而调控基因表达,miRNA的异常表达通常与病理疾病有关.据报道miR-15a-5p在房颤患者中表达...
miR-15a-5p bound to Caspase-1 and inhibited Caspase-1 expression. Inhibiting miR-15a-5p or overexpressing Caspase-1 partially reversed the inhibitory effect of si-HDAC1 on kainic acid-induced cell pyroptosis. In conclusion, HDAC1 aggravates hippocampal neuronal pyroptosis in SE via the miR-15a-5p...