miR-15a-5p 与 Caspase-1 结合并抑制其表达。抑制 miR-15a-5p 或过表达 Caspase-1 部分逆转了 si-HDAC1 对海人酸诱导的细胞焦亡的抑制作用。总之,HDAC1 通过 H3K9 去乙酰化,经 miR-15a-5p/Caspase-1 轴加重 SE 中海马神经元焦亡。
所述miR‑15a‑5p或修饰的miR‑15a‑ 5p具有生物活性,可在体外被细胞吸收,或者在 体内被视网膜细胞吸收 ,并迅速发挥生物学作 用。通过局部给药的方式,所述miR‑15a‑5p或修 饰的miR‑15a‑5p可以抑制病理性新生血管、促进 无灌注区恢复、减少视网膜炎症因子表达、减轻 视网膜纤维化并促进神经损伤修复...
货号:mdo-miR-15a-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:mdo-miR-15a-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
MicroRNA-15a-5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF. Tumour Biol. 2016;37:5821–8. CAS PubMed Google Scholar Alderman C, Sehlaoui A, Xiao Z, Yang Y. MicroRNA-15a inhibits the growth and invasiveness of malignant melanoma and ...
15a-5p/ 16-5p.What's more,miR-15a-5p/ 16-5p could regulate the expression of CCND1 by targeting the putative binding site CCND1-b.%目的:构建miR-15a-5p和miR-16-5p的荧光素酶报告载体,利用此载体分析并验证miR-15a-5p和miR-16-5p与CCND1基因3'-UTR区域的确切结合位点,探讨miR-15a-5p...
Plasma-derived exosomal miR-15a-5p as a promising diagnostic biomarker for early detection of endometrial carcinoma_2021_Lanyun 上传人:jrvbib315·上传时间:2022-11-21 1/6 0% 0% 0% 0% 0% 继续阅读
人 miR-15a 的茎环结构和 miRNA 表达量 这样，前一个应该就清楚了：miR-339-5p：miRNA 339 5' 端...
Briefly, miR-15a-5p biotin probe, miR-15a-5p no-biotin probe or miR-15b-5p biotin probe, miR-15b-5p no-biotin probe were separately synthesized by Thermo Fisher Scientific. The biotinylated microRNA (miRNA) was incubated overnight with cell lysates (Millipore, Billerica, MA, USA), followed...
Interestingly, miR-15a-5p downregulated by ARFRP1 negatively modulated TLR4 expression through interaction. ARFRP1 mediated LPS-induced the injury of chondrocytes via regulating miR-15a-5p/TLR4 axis. Furthermore, ARFRP1 exerted function by modulation of NF-κB pathway. Significance Our findings ...