2009. Dopamine D2 and adenosine A2A receptors reg- ulate NMDA-mediated excitation in accumbens neurons through A2A-D2 receptor heteromerization. Neuropsycho- pharmacology 34:972-986.Azdad K, Gall D, Woods AS, Ledent C, Ferre S, Schiffmann SN (2009). Dopamine D2 and adenosine A2A receptors...
Breakthroughs such as the first ligand-bound X-ray structure of a selective adenosine A2A receptor antagonist in complex with the adenosine A2A receptor, the discovery of the existence of dopamine D2 homodimers, dopamine D2- adenosine A2A heterodimers and higher order oligomers in addition to ...
Antagonistic A2A/D2 receptor interactions in the striatum as a basis for adenosine—dopamine interactions for the central nervous system. Drug Dev Res. 1993; 28 :374–380.Fuxe, K., S. Ferre´ , P. Snaprud, G. V. Euler, B. Johansson, and B. Fredholm. Antagonistic A2a/D2 receptor ...
腺苷A2A受体(Adenosine 2A receptor,A2AR)是腺苷受体家族的一员,特异性表达于纹状体间接通路神经元【4】。A2AR可通过相互拮抗的方式调控多巴胺D2受体(dopamine D2 receptor,D2R)和谷氨酸N-甲基-D-天门冬氨酸受体(NMDA glutamate receptor,...
腺苷A2A受体(Adenosine 2A receptor,A2AR)是腺苷受体家族的一员,特异性表达于纹状体间接通路神经元【4】。A2AR可通过相互拮抗的方式调控多巴胺D2受体(dopamine D2 receptor,D2R)和谷氨酸N-甲基-D-天门冬氨酸受体(NMDA glutamate receptor,NMDAR),且以相互协同的方式调控5型代谢性谷氨酸受体(metabotropic glutamate rece...
The D2 receptors were functional: an agonist, quinpirole, could stimulate GTPγS binding and reduce stimulated adenylyl cyclase activity. The A2A receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine (CGS 21680) decreased high-affinity binding of the agonist dopamine ...
moements and rotational responses during chronic L-DOPA treatment, similar to mice that receied low doses of A2A receptor antagonists along with L-DOPA.这些小鼠在长期左旋多巴治疗过程中表现出较少的异常不自主运动以及轮替反应，与接受低剂量阿糖腺苷A2A受体拮抗剂加左旋多巴处理的小鼠类似。
Membranes from transfected cells showed a high density of D2 (3.6 pmol per mg protein) and A2A receptors (0.56 pmol per mg protein). The D2 receptors were functional: an agonist, quinpirole, could stimulate GTPγS binding and reduce stimulated adenylyl cyclase activity. The A2A receptor ...
A2AreceptorantagonistKW-6002ondrag—inducedcatalepsyand hypokinesiacausedbyreserpineorMPTP[J].Psychopharmacolo— gY,1999,147(1):90—5. [17]ChenJF,MoratallaR,ImpagnatielloF,eta1.TheroleoftheD2 dopaminereceptor(D2R)inA2Aadenosinereceptor(A2AR)-me— diatedbehavioralandcellularresponsesasrevealedbyA2Aand...
Keywords:adenosine;A2Areceptor;immunoregulation 免疫调节是机体保持内环境稳定、抵御外来有害刺激的重要手段。腺 苷,作为机体的一种重要递质及调质,在代谢障碍及细胞损伤时会大幅升 高,激活腺苷受体而収挥生物学效应,参不机体的免疫调节。近来研究表 明,在缺血低氧、炎症、创伤、移植等诸多病理过程中,腺苷A2A受体的 ...