Adenosine-to-inosine RNA editing is a conserved process, which is performed by ADAR enzymes. By changing nucleotides in coding regions of genes and altering codons, ADARs expand the cell's protein repertoire. This function of the ADAR enzymes is essential for human brain development. However, ...
近日,刘慧泉教授团队在Nature Communications上在线发表了题为“Unveiling the A-to-I mRNA editing machinery and its regulation and evolution in fungi” 的研究论文,该研究以小麦赤霉病菌为研究材料,揭示了真菌中A-to-I mRNA编辑的酶复合体,并明确了其起源、进化和调控机制。研究结果对真菌病害防控和基因编辑工...
课题组应邀在Springer Nature Research Communities上分享了该科学发现:Unveiling the Mystery of Fungal RNA Editing Machinery: A Story of Unexpected Discoveries (https://communities.springernature.com/posts/unveiling-the-mystery-of-fungal-rna-editing-machinery-a-story-of-unexpected-discoveries) 参考文献: 1....
该研究主要开发了一种名为RtABE(RNA transformer adenosine base editor)的新型RNA编辑系统,通过引入ADAR抑制剂(ADI)来抑制ADAR2脱氨酶的活性,从而实现高效且特异性的RNA A-to-I编辑,并在Hurler综合征小鼠模型中成功纠正了α-l-iduronidase活性缺陷,且未检测到显著的非靶向编辑。 导读 与基因组编辑不同,RNA编辑...
近日,中国科学院生物化学与细胞生物学研究所陈玲玲研究组与中科院-马普计算生物学研究所杨力研究组合作的最新研究成果,以N6-methyladenosines modulate A-to-I RNA editing为题,发表在Molecular Cell上,研究揭示了两种较为普遍存在的RNA水平修饰-腺苷N6位置上的甲基化(m6A)和腺苷至次黄苷碱基编辑(A-to-I editing)之间...
2024年8月10日,香港中文大学于君/黄子隽团队在Protein & Cell上发表了综述文章Adenosine-to-Inosine RNA editing in cancer: molecular mechanisms and downstream targets。本篇综述尝试总结A-to-I RNA修饰领域的最新进展,特别强调A-...
2021年5月17日,北京大学生命科学学院陆剑研究员课题组在WIREs RNA发表题为“Evolutionary driving forces of A-to-I editing in metazoans”的综述论文。 由ADAR(adenosine deaminase acting on RNA)蛋白介导的腺嘌呤到次黄嘌呤(A-to-I)的RNA编辑是后生动物中广泛存在的转录后修饰。由于I会被识别为G,因此A-to-...
A-to-I RNA editing Adenosine deaminases acting on RNA (ADARs) enzymes are responsible for catalyzing A-to-I editing in double-stranded RNA (dsRNA). Three ADAR genes—ADAR1, ADAR2, and ADAR3—have been identified in the human genome, each containing two to three N-terminal dsRNA-binding ...
Modifications of RNA affect its function and stability. RNA editing is unique among these modifications because it not only alters the cellular fate of RNA molecules but also alters their sequence relative to the genome. The most common type of RNA editi
2021年5月17日,北京大学生命科学学院陆剑课题组在《WIREs RNA》上发表了题为“Evolutionary driving forces of A-to-I editing in metazoans”的综述论文。 由ADAR(adenosine deaminase acting on RNA)蛋白介导的腺嘌呤到次黄嘌呤(A...