Inosine is also recognized as guanosine by splicing and translation machineries, resulting to mRNA alternative splicing and protein recoding. Therefore, A-to-I RNA editing is an important mechanism that causing and regulating "RNA mutations" in both normal physiology and diseases, such as cancers. ...
Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by the ADAR (adenosine deaminases acting on RNA) family of enzymes1,2,3,4, is the most common form of RNA editing among animals5. As the translation machinery largely interprets inosines as guanosines6editing within the coding sequence ...
Adenosine-to-inosineRNAeditingBorisZinshteyn1,*andKazukoNishikura11TheWistarInstitute,GeneExpressionandRegulation,Philadelphia,PA19104,USAAbstractRibonucleicacid(RNA)editingisamechanismthatgeneratesRNAandproteindiversity,whichisnotdirectlyencodedinthegenome.ThemostcommontypeofRNAeditinginvertebratesistheconversionofadenosin...
A-to-I RNA editing is a post-transcriptional modification that converts adenosines to inosines in both coding and noncoding RNA transcripts. It is catalyzed by ADAR (adenosine deaminase acting on RNA) enzymes, which exist throughout the body but are most prevalent in the central nervous system...
The adenosine to inosine (A-to-I) editing is the most prevalent kind of RNA editing and involves in many biological processes. Accurate identification of A-to-I editing site is invaluable for better understanding its biological functions. Due to the limitations of experimental methods, in the pr...
Adenosine-to-inosine (A-to-I) RNA editing by the adenosine deaminase that acts on RNA (ADAR) enzymes is a common RNA modification, preventing false activation of the innate immune system by endogenous double-stranded RNAs. Methods for quantification of ADAR activity are sought after, due to an...
Adenosine DeaminaseIn metazoan cells, transcripts that fold into double-strand RNA structures are endowed with the capacity to undergo A-to-I RNA editing,... JEC Jepson,RA Reenan - Fly 被引量: 12发表: 2010年 Mycophenolate and nephrology Inhibition of inosine 5 -monophospate dehydrogenase (IMPDH...
Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila. The accurate and thorough genome-wide detection of adenosine-to-inosine editing, a biologically indispensable process, has proven challenging. Here, we pre... St,Laurent,Georges,... - 《Nature Structural & ...
Adenosine-to-inosine (A-to-I) RNA editing leads to transcriptome diversity and is important for normal brain function. To date, only a handful of functiona... BL Jin,EY Levanon,JK Yoon,... - 《Science》 被引量: 769发表: 2009年 Bone Mass Is Low in Relatives of Osteoporotic Patients ...
pseudo nucleotide compositions received: 23 August 2016 accepted: 20 September 2016 Published: 11 October 2016 Wei Chen1, Pengmian Feng2, Hui Ding3 & Hao Lin3 The adenosine to inosine (A-to-I) editing is the most prevalent kind of RNA editing and involves in many biological ...