Modifications of RNA affect its function and stability. RNA editing is unique among these modifications because it not only alters the cellular fate of RNA molecules but also alters their sequence relative to the genome. The most common type of RNA editi
1. Eisenberg E, Levanon EY. A-to-I RNA editing - immune protector and transcriptome diversifier.Nat Rev Genet.2018;19: 473–90 2. Liddicoat BJ, et al. RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.Science. 2015;349:1115–20 3. Rice GI, et al. Mutations...
Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA modification within the brain. Yet, most research has relied on postmortem samples, assuming it is an accurate representation of RNA biology in the living brain. We challenge this assumption by comparing A-to-I editin...
Moreover, the 2′-OH group in RNA is chemically active and is able to initiate a nucleophilic attack on the adjacent 3′ phosphodiester bond in an SN2 reaction. This cleaves the RNA sugar-phosphate backbone and this chemical mechanism underlies the basis of catalytic self-cleavage observed in ...
Gene-edited stem cells have come to the fore along with the advances of novel gene-editing technologies, notably the CRISPR-Cas system69, which allowed removing, inserting, or modifying genetic information in a DNA sequence. This innovative and attractive strategy has revolutionized both biological ...
In this review, we made an attempt to create a holistic picture of plant response to a rising temperature environment and its impact by covering all aspect
In particular, and in relation to RNA, it is now well established that endogenous self RNA transcripts can form double-stranded RNAs (dsRNAs) resembling pathogen-derived dsRNAs and can be thus recognized as non-self by cytosolic RNA sensing receptors [2]. These, in turn, would activate type ...
However, it has recently been shown that cyanobacteria represent the smallest and oldest organisms to use a kind of camera eye micro-optic for sensing light direction: individual Synechocystis cells directly sense the position of the light source through their own cells that act as micro-lenses [...
cells. Research indicates that changes in A-to-I editing in cancer cells may promote tumor growth and confer resistance to apoptosis [6,7,8]. A-to-I editing can influence gene expression by altering mRNA splicing, RNA localization, microRNA (miRNA) binding, and transcript stability [9]. ...
The aim of remote sensing image fusion is to merge the high spectral resolution multispectral (MS) image with high spatial resolution panchromatic (PAN) image to get a high spatial resolution MS image with less spectral distortion. The conventional pixel level fusion techniques suffer from the halo...