\\u00a0-Conotoxins, a New Family of Conotoxins with Unique Disulfide Pattern and Protein Folding: ISOLATION AND CHARACTERIZATION FROM THE VENOM OF CONUS MA... Balaji,R.,A.,... - 《Journal of Biological Chemistry》 被引量: 236发表: 2000年 Lambda-conotoxins, a new family of conotoxins ...
α-Conotoxin PnIA是一种从海洋腹足类动物Conus pennaceus（又称筒箭毒蜗牛）中提取的多肽毒素，具有抑制烟碱型乙酰胆碱受体（nAChRs）的功能。α-Conotoxin PnIA最初被发现为一种竞争性抑制剂，能够结合并阻断α3β2 nAChRs，但对α7 nAChRs的亲和力较低。然而，通过在第10位引入亮氨酸（Leu）替换丙氨酸（Ala），...
A major advance in recent years in the neuropharmacology of nAChRs has been the ability to characterize particular neuronal subtypes more readily by using specific conotoxins. We now report the cloning of a gene encoding a novel peptide of the α-conotoxin family from Conus pergrandis,α-...
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Conotoxins have been previously grouped into superfamilies according to signal sequence and into families based on their cysteine framework and biological target. Here we describe the cloning and characterization of a new conotoxin, from Conus vexillum, named ±B-conotoxin VxXXIVA. The peptide does ...
Lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding:Isolation and characterization from the venom of Conus marm... Journal of Biological ChemistryBalaji,R. A. et al.lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein...
Conotoxins (conopeptides) are small disulfide bonded peptides from the venom of marine cone snails. These peptides target a wide variety of membrane recept... DJ Adams,B Callaghan,G Berecki - 《British Journal of Pharmacology》 被引量: 94发表: 2012年 ...
Cal14.1a has not been found using NMR or X-ray crystallography, so homology modeling had to be carried out, and a structure for cal14.1a was obtained. This structure was compared with those obtained from the modeling results of the cal14.1a and cal14.1b conotoxins reported by Oroz et al...
芋螺毒素(conotoxins,CTx)是近年来国际上的一个研究热点.它是肉食性软体动物芋螺(conus)分泌出来的能特异性作用于体内各种离子通道及神经受体的生物活性多肽化合物,通... 张伟 - 同济大学 被引量: 2发表: 2006年 新型芋螺毒素K411基因在毕赤酵母中的表达研究 芋螺毒素(conotoxin,conopeptide,CTX)是近年来国际上...
芋螺毒素 (conotoxin ,CTx)是一类具有神经药理活性的多肽。由于芋螺毒素的多样性而成为新的进化选择性物质的组合库。芋螺毒素富含二硫键 ,具有作用于神经系统内的分子... 黄凤玲 - 《国外医学.药学分册》 被引量: 14发表: 2001年 芋螺毒素的基因克隆、表达及分离纯化的研究 芋螺毒素(conotoxins,CTx)是近年来国际...