We describe a strategy for the efficient, unambiguous assignment of disulfide connectivities in α-conotoxin SII, of which 30% of its mass is cysteine, as an example of a generalizable technique for investigation of cysteine-rich peptides. α-Conotoxin SII was shown to possess 3–8, 2–18,...
BuIA[T5A;P6O] is a novel ligand for distinguishing between closely related α6* nAChRs; α6β4* nAChRs modulate norepinephrine release in hippocampus but not dopamine release in striatum. 展开 关键词: Animals Mice, Inbred C57BL Xenopus Mice Oocytes Nicotine Proline Conotoxins Receptors, ...
\\u00a0-Conotoxins, a New Family of Conotoxins with Unique Disulfide Pattern and Protein Folding: ISOLATION AND CHARACTERIZATION FROM THE VENOM OF CONUS MA... Balaji,R.,A.,... - 《Journal of Biological Chemistry》 被引量: 236发表: 2000年 Lambda-conotoxins, a new family of conotoxins ...
α-Conotoxin PnIA是一种从海洋腹足类动物Conus pennaceus（又称筒箭毒蜗牛）中提取的多肽毒素，具有抑制烟碱型乙酰胆碱受体（nAChRs）的功能。α-Conotoxin PnIA最初被发现为一种竞争性抑制剂，能够结合并阻断α3β2 nAChRs，但对α7 nAChRs的亲和力较低。然而，通过在第10位引入亮氨酸（Leu）替换丙氨酸（Ala），...
Conotoxins 是对烟碱的醋胆素受体(nAChRs ) 的特定的子类型作为有势力和选择对手起作用的小抑制二硫化物的肽.我们以前从食虫的 Conus leopardus 从 molluscivorous Conus marmoreus 和 Lp1.4 克隆二 -conotoxins, Mr1.1.他们俩有 -conotoxins 的亚科的典型 4/7-type 框架 neuronal nAChRs 上的那行为.在这个工作...
芋螺毒素 (conotoxin ,CTx)是一类具有神经药理活性的多肽。由于芋螺毒素的多样性而成为新的进化选择性物质的组合库。芋螺毒素富含二硫键 ,具有作用于神经系统内的分子... 黄凤玲 - 《国外医学.药学分册》 被引量: 14发表: 2001年 芋螺毒素的基因克隆、表达及分离纯化的研究 芋螺毒素(conotoxins,CTx)是近年来国际...
We now report the cloning, total synthesis, and characterization of a novel toxin α-conotoxin PeIA that discriminates between α9α10 and α7 nAChRs. This is the first toxin to be identified from Conus pergrandis, a species found in deep waters of the Western Pacific. α-Conotoxin PeIA ...
世联博研公司现货供应MYBIOSOURCE INC.品牌订货号为MBS1010597的Recombinant Conus spurius Alpha-conotoxin SrIA/SrIB from MYBIOSOURCE INC.产品
Conotoxins have been previously grouped into superfamilies according to signal sequence and into families based on their cysteine framework and biological target. Here we describe the cloning and characterization of a new conotoxin, from Conus vexillum, named ±B-conotoxin VxXXIVA. The peptide does ...
Conotoxins (conopeptides) are small disulfide bonded peptides from the venom of marine cone snails. These peptides target a wide variety of membrane recept... DJ Adams,B Callaghan,G Berecki - 《British Journal of Pharmacology》 被引量: 94发表: 2012年 ...