BiologyGeneticsChemistry Oxidative folding of conotoxins| Chemical and biological developments to efficiency of production of shortcysteine-rich peptides THE UNIVERSITY OF UTAH Grzegorz Bulaj SteinerAndrew MOxidative folding is one of the key challenges hampering the development of peptide-based compounds ...
2013, Future Medicinal Chemistry* Dr. Teichert is disclosing that he is currently employed by Vertex Pharmaceuticals, San Diego, CA. His entire contribution to this chapter was completed while he was previously employed as a Research Assistant Professor, Department of Biology, University of Utah. Dr...
Fifty Years of Animal Toxin Research at the Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS In marine animals, versatile toxins in terms of structure and molecular targets were discovered, and careful work on α-conotoxins differing in specificity ... V Tsetlin,I Shelukhina,S Kozlov,...
- 《Journal of Biological Chemistry》 被引量: 113发表: 2003年 Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels Conotoxins (conopeptides) are small disulfide bonded peptides from the venom of marine cone snails. These peptides target a ...
,... - 《Journal of Biological Chemistry》 被引量: 84发表: 2004年 Conotoxin Gene Superfamilies Unique potency and selectivity profiles for a range of neuronal targets have made several conotoxins valuable as research tools, drug leads and even ... S Robinson,R Norton - 《Marine Drugs》 被...
Acta Pharmacol Sin 2009 Jun; 30 (6): 771–783 npg Review Alpha-conotoxins as pharmacological probes of nicotinic acetylcho- line receptors Layla AZAM1,*, J Michael MCINTOSH1,2 1Department of Biology and 2Department of Psychiatry, University of Utah, Salt Lake City, UT 84112, USA Cysteine-...
- 《Journal of Biological Chemistry》 被引量: 400发表: 1996年 Targeting chronic and neuropathic pain: The N-type calcium channel comes of age The rapid entry of calcium into cells through activation of voltage-gated calcium channels directly affects membrane potential and contributes to electrica.....
delta-conotoxins mainly remove the fast inactivation of Na(v) channels and, thus, functionally resemble long-chain scorpion alpha-toxins. microO-conotoxins are functionally similar to micro-conotoxins, since they inhibit the ion flow through Na(v) channels. Recent results from functional and ...
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After the desired amino acid sequence has been completed, the intermediate peptide can be removed from the resin support by treatment with a reagent, such as liquid hydrogen fluoride or TFA (if using Fmoc chemistry), which not only cleaves the peptide from the resin but also cleaves all ...