alpha - CONOTOXIN - IMI - BINDING AND alpha7 EXPRESSION PATTERNS IN THE RAT NEOCORTEX AND HIPPOCAMPUS DURING POSTNATAL DEVELOPMENTBrink, SGro, AUtkin, Y NTsetlin, V ISchrder, HLindstrom, JWevers, A
The use of α-conotoxin ImI to actualize the targeted delivery of paclitaxel micelles to α7 nAChR-overexpressing breast cancer. Biomaterials. 2015; 42: 52-65.Mei D, Lin Z, Fu , et ol. The use of ct-conotoxin ImI to actu- alize the targeted delivery of paclitaxel micelles to ct7 ...
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For α-CTx ImI: light blue represents backbone structure; yellow, disulfide bonds; dark blue, side chain of Arg7; green, side chain of Trp10; gray, other "non- essential" toxin residues. (B) Superimposed ribbon diagrams of six α4/7-conotoxins: α-conotoxins PIA (violet), MII (blue...
Examines alpha-conotoxin (a-CTx) ImII and ImI from the marine snail Conus imperialis. Similarities in the amino acids of a-CTx ImII and ImI; Biological activities of intracranially applied a-CTx ImII and ImI; Functional binding sites of a-CTx.Ellison...
(2011) Blockade of neuronal a7- nAChR by a-conotoxin ImI explained by computational scanning and energy calculations. PLOS Comput. Biol. 7, e1002011R. Yu, D.J. Craik, Q. Kaas, Blockade of neuronal a7-nAChR by a-conotoxin ImI explained by computat...
EpI has homology to sequences of previously described alpha-conotoxins, particularly PnIA, PnIB, and ImI. However, EpI differs from previously reported conotoxins in that it has a sulfotyrosine residue, identified by amino acid analysis and mass spectrometry. Native EpI was shown to coelute ...
stagnalis: [D14K] mutation affected only slightly the potency of [A10L]PnIA to block nAChRs on neurons with low sensitivity to alpha-conotoxin ImI, but gave a 50-fold enhancement of blocking activity in cells with high sensitivity to ImI. Therefore, the introduction of an additional positive...
Quiram PA,Sine SM.Identification of residues in the neuronal alpha7 acetylcholine receptor that confer selectivity for conotoxin ImI. Journal of Biological Chemistry . 1998Quiram PA, Sine SM. Identification of residues in the neuronal α7 acetylcholine receptor that confer selectivity for conotoxin ImI...
The natural a conotoxin α-CTx ImI was successfully modified to give a new peptide with a much slower off rate from the α7 subtype nAChR.The University of Utah.Ellison, Michael Arthur.The University of Utah.